Single Chain Kininogen
Single Chain Kininogen is a nonenzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor -Xlla. HK also forms a complex with Factor XI and accelerates its activation to XIa by -Xlla. Also HK serves as a source of Bradykinin, a potent Vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE.