Rat Prolactin Receptor, chiMAX Fc Fusion Protein
Prolactin is a neuroendocrine peptide hormone that is secreted primarily by the pituitary gland. Prolactin receptor is a class 1 cytokine transmembrane receptor that varies in size with tissue source and species. It consists of an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region. The extracellular domain (Ser21-Asp229) is expressed recombinantly, purified by chromatography, sterile filtered and lyophilized. 95 percent pure by SDS-PAGE and biologically active as measured by inhibitory activity toward prolactin-induced proliferation of Nb2-11 rat lymphoma cells.