Kininogen Deficient Products

Kininogen Genetically Deficient (Knockout) Products are applicable to a wide range of in vitro research applications (including ELISA and Western Blot) and for many different areas of research, including blood pressure, inflammation, and pain response as well as in cardiovascular studies into intrinsic/pathway coagulation and hypertension research. 

Our Kininogen Knockout was created by targeted disruption of the KNG1 gene. Mutations were then confirmed using PCR genotyping and Sanger sequencing. These knockouts demonstrate a complete absence of Kininogen protein in plasma, as confirmed by Western Blot, along with extended clotting time.

Products available include genetically deficient plasma, organs (flash-frozen), lyophilized organ powders, and ready-to-use organ tissue lysates. These products are ideal for use as standards or controls, including use as a negative control. 

We also offer Knockout Mice, available as individual male and/or female mice as well as breeding pairs. These Research Models are fully licensed and maintained as live colonies with immediate availability. Contact us directly for more information about live Research Models.