Product References — Pooled Human Serum Off The Clot

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Effect of Intravenous Immunoglobulin (IVIg) on Primate Complement-Dependent Cytotoxicity of Genetically Engineered Pig Cells: Relevance to Clinical Xenotransplantation Takayuki Yamamoto, Yehua Cui, Diyan Patel, Abhijit Jagdale, Hayato Iwase, David Ayares, David K. C. Cooper & Hidetaka Hara Scientific Reports July 16, 2020 Triple-knockout (TKO) pigs are thought to be ideal sources of organs for clinical xenotransplantation because many humans have no preformed antibody to TKO pig cells. Pig kidney or heart graft survival in nonhuman primates (NHPs) now extends to many months, or in...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Old World Monkeys are Less than Ideal Transplantation Models for Testing Pig Organs Lacking Three Carbohydrate Antigens (Triple-Knockout) Takayuki Yamamoto, Hayato Iwase, Diyan Patel, Abhijit Jagdale, David Ayares, Douglas Anderson, Devin E. Eckhoff, David K. C. Cooper & Hidetaka Hara Scientific Reports June 17, 2020 Choosing the best nonhuman primate (NHP) model to perform pig-to-NHP xenotransplantation is crucial to determine the feasibility of pig organ transplantation in humans. Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to be optimal sources of organs...

Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Analysis of Human Erythropoietin and Erythropoietin N-Linked Glycans Using Capillary Electrophoresis and Mass Spectrometry Jessica M. Risley University of British Columbia June 2020 Proteins with attached sugars can be used to treat illnesses. It is important to study the sugar component of the protein because the sugars are often complex and can cause negative immune system reactions. Glycans are the complex branched oligosaccharides which are covalently linked to protein molecules. Characterization of the glycan component of glycoproteins is challenging due to microheterogeneity, but necessary...

Pooled Human Urine and Pooled Human Serum Off The Clot from Innovative Research was used in the following study:   Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography–triple quadrupole mass spectrometry method for determination of intact growth factor proteins Alex J. Rai Kevin A. Schug, Katarína Maráková Journal of Separation Science 2/7/2020 “In biological systems, variable protein expression is a crucial marker for numerous diseases, including cancer. The vast majority of liquid chromatography–triple quadrupole mass spectrometry-based quantitative protein assays use bottom-up methodologies, where proteins are subjected to proteolytic cleavage prior to analysis. …As biological...