Rabbit Anti STAT1 Polyclonal Affinity Purified (PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.) (Western Blot,IHC)IRBAMLSTAT1AP052120UL
Rabbit Anti STAT1 Polyclonal Affinity Purified (PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.) (Western Blot,IHC) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. This antibody has been affinity purified.
- Host: Rabbit
- Species: Human,Rat
- Target: STAT1
- Clonality: Polyclonal
- Purity: Affinity Purified
- Immunogen: Recombinant human Zinc finger protein SNAI1 protein
- Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
This product can be used in analytical tools such as Western Blot,IHC.
At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.
For research use only.
This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.
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