{"product_id":"rabbit-anti-rb1-polyclonal-affinity-purified-819","title":"Rabbit Anti RB1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence)","description":"\u003cp\u003eRabbit Anti RB1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 50% glycerol, pH7.3 This antibody has been affinity purified.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eHost:\u003c\/b\u003e Rabbit\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human,Mouse\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e RB1\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eClonality:\u003c\/b\u003e Polyclonal\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e Affinity Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e Recombinant fusion protein of human Rb (NP_000312.2).     \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store at -20°C. Avoid freeze \/ thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. \u003c\/p\u003e\u003cp\u003eThis product can be used in analytical tools such as Immunofluorescence.\u003c\/p\u003e\u003cp\u003eAt Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"120ul","offer_id":41660172959940,"sku":"IRBAMLRB1AP819120UL","price":367.0,"currency_code":"USD","in_stock":true},{"title":"200ul","offer_id":41660172992708,"sku":"IRBAMLRB1AP819200UL","price":540.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/f57f0ce8-b3b6-4e8b-b35d-92cb2b78a992_895e4fdb-1d21-444e-9720-ed4c28c5233d.jpg?v=1739997674","url":"https:\/\/www.innov-research.com\/products\/rabbit-anti-rb1-polyclonal-affinity-purified-819","provider":"Innovative Research","version":"1.0","type":"link"}