{"product_id":"rabbit-anti-jun-polyclonal-affinity-purified-029","title":"Rabbit Anti JUN Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)","description":"\u003cp\u003eRabbit Anti JUN Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 This antibody has been affinity purified.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eHost:\u003c\/b\u003e Rabbit\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human,Mouse\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e JUN\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eClonality:\u003c\/b\u003e Polyclonal\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e Affinity Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e KLH conjugated Synthetic peptide corresponding to Mouse c- JUN\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store at -20°C. Avoid freeze \/ thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eJUN is also named as c-Jun and  AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.\u003c\/p\u003e\u003cp\u003eThis product can be used in analytical tools such as IHC.\u003c\/p\u003e\u003cp\u003eAt Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"120ul","offer_id":41544329887940,"sku":"IRBAMLJUNAP029120UL","price":298.0,"currency_code":"USD","in_stock":true},{"title":"200ul","offer_id":41544329920708,"sku":"IRBAMLJUNAP029200UL","price":418.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/f57f0ce8-b3b6-4e8b-b35d-92cb2b78a992_f84ef325-13f8-4ee6-ade4-6c75d279c85a.jpg?v=1739995929","url":"https:\/\/www.innov-research.com\/products\/rabbit-anti-jun-polyclonal-affinity-purified-029","provider":"Innovative Research","version":"1.0","type":"link"}