{"product_id":"rabbit-anti-human-bora-polyclonal-antigen-affinity-purified-604","title":"Rabbit Anti Human BORA Polyclonal Antigen affinity Purified (PBS with 0.05% NaN3 and 40% Glycerol, pH7.4) (Western Blot,IHC,ELISA)","description":"\u003cp\u003eRabbit Anti Human BORA Polyclonal Antigen affinity Purified (PBS with 0.05% NaN3 and 40% Glycerol, pH7.4) (Western Blot,IHC,Sandwich ELISA) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 This antibody has been antigen affinity purified.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eHost:\u003c\/b\u003e Rabbit\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e BORA\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eClonality:\u003c\/b\u003e Polyclonal\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e Antigen affinity Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmunogen:\u003c\/b\u003e Synthetic peptide of human BORA\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store at -20°C. Avoid freeze \/ thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAurora related kinase-1 (ARK-1) is a centrosome-associated serine\/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.\u003c\/p\u003e\u003cp\u003eThis product can be used in analytical tools such as Western Blot,IHC,Sandwich ELISA.\u003c\/p\u003e\u003cp\u003eAt Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e \u003cbr\u003e\u003ca href=\"https:\/\/youtu.be\/J7fuMk6JfyI?si=cvhwIRlxjJlTCI3m\"\u003eClick here\u003c\/a\u003e to view a video tutorial covering frequently asked questions regarding ELISA workflows.","brand":"Innovative Research","offers":[{"title":"120ul","offer_id":41475258056900,"sku":"IRBAHUBORAAAP604120UL","price":275.0,"currency_code":"USD","in_stock":true},{"title":"200ul","offer_id":41475258089668,"sku":"IRBAHUBORAAAP604200UL","price":427.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/f57f0ce8-b3b6-4e8b-b35d-92cb2b78a992_6511414a-8313-4894-8071-9ba28ad4788c.jpg?v=1739994291","url":"https:\/\/www.innov-research.com\/products\/rabbit-anti-human-bora-polyclonal-antigen-affinity-purified-604","provider":"Innovative Research","version":"1.0","type":"link"}