{"product_id":"mouse-pdcd1-recombinant-protein-c-fc-tag-lyophilized-50ug","title":"Mouse PDCD1 Recombinant Protein C-Fc Tag Lyophilized","description":"Mouse PDCD1 Recombinant Protein C-Fc Tag Lyophilized from Innovative Research has been recombinantly produced in Human Cells. This is a Lyophilized protein buffered in Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH8.0. It is not recommended to reconstitute to a concentration less than 100UG\/ml. Dissolve the lyophilized protein in ddH2O. with a purity of Greater than 95% as determined by reducing SDS-PAGE.Endotoxin level less than 0.1 ng\/ug (1 IEU\/ug) as determined by LAL test..More Details: Species: Mouse Target: Pdcd1 Purity: Greater than 95% as determined by reducing SDS-PAGE.Endotoxin level less than 0.1 ng\/ug (1 IEU\/ug) as determined by LAL test. Source: Human Cells Storage Conditions: Lyophilized protein should be stored at -20░C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7░C for 2-7 days.Aliquots of reconstituted samples are stable at -20░C for 3 months. \u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003eProgrammed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28\/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.This recombinant protein can be used for biological assays. For research use only. . At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.","brand":"Innovative Research","offers":[{"title":"50UG","offer_id":40681303933124,"sku":"IMSPDCD1RCFCLY50UG","price":508.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_f228e056-a6eb-4d1c-a08c-9f39d86b45b9.jpg?v=1740022923","url":"https:\/\/www.innov-research.com\/products\/mouse-pdcd1-recombinant-protein-c-fc-tag-lyophilized-50ug","provider":"Innovative Research","version":"1.0","type":"link"}