Mouse PAI-1 Genetically Deficient Heart

Mouse PAI-1 Genetically Deficient Heart

IMSPAI1GDHT2

Innovative Research

  • $190.00


Select this product for Molecular Innovations name, Mouse PAI-1 genetically deficient heart and product number, MPAI-KO-HT

Mouse PAI-1 Genetically Deficient Heart from Innovative Research has been collected and flash frozen from homozygous PAI-1 knockout mice of strain B6.129S2-Serpine1 tm1Mlg /J. The targeted PAI-1 knockout mutation was made on the C57BL/6J background strain. Mice homozygous for this mutation develop normally and are viable and fertile. This product is in frozen tissue format.

More Details:

  • Species: Mouse
  • Source: PAI-1 Knockout Mouse
  • Gene Name: SERPINE1
  • UniProt ID: P22777
  • Format: Frozen
  • Storage Conditions: Store at -70°C for up to 3 years
  • Shipping: Dry Ice

Additional Information:
This organ is an ideal negative control for western blotting, immunoprecipitation, immunohistochemistry and other experiments involving PAI-1. Compared to wild type mice, pulmonary clot lysis is increased in the heterozygote and further increased in the homozygote. Endotoxin induced venous thrombosis is decreased compared to wild type mice. Thus, disruption of the Serpine1 gene induces a mild hyperfibrinolytic state. Hemostasis is normal in homozygous mutants.

Optimal experimental conditions and working dilutions must be determined by the end user. For research use only. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

Select this product for Molecular Innovations name, Mouse PAI-1 genetically deficient heart and product number, MPAI-KO-HT

Product References
Product Disclaimer

This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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