{"product_id":"mouse-il-23-recombinant-protein-fc-tag-lyophilized-50ug","title":"Mouse IL-23 Recombinant Protein Fc Tag Lyophilized","description":"\u003cp\u003eMouse IL-23 Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 and#956;g\/ml in sterile PBS. with a purity of \u0026gt;98% (SDS-PAGE).\u003cbr\u003e\u003cbr\u003e Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza)..\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Mouse \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e Il12b\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e \u0026gt;98% (SDS-PAGE).\u003cbr\u003e\u003cbr\u003e Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza). \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e CHO cells \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eInterleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 Rbeta1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naie and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8-and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor\/self peptide.\u003cp\u003eThis recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"50UG","offer_id":40402739986628,"sku":"IMSIL23RFCLY50UG","price":808.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_1c396266-ae96-4191-b4ac-831cc9c7f93c.jpg?v=1740021321","url":"https:\/\/www.innov-research.com\/products\/mouse-il-23-recombinant-protein-fc-tag-lyophilized-50ug","provider":"Innovative Research","version":"1.0","type":"link"}