{"product_id":"mouse-il-21r-non-lytic-recombinant-protein-fc-tag-lyophilized-25ug","title":"Mouse IL-21R non-lytic Recombinant Protein Fc Tag Lyophilized","description":"\u003cp\u003eMouse IL-21R non-lytic Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 and#956;g\/ml in sterile PBS. with a purity of \u0026gt;98% (SDS-PAGE).\u003cbr\u003e\u003cbr\u003e Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza)..\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Mouse \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e Il21r\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e \u0026gt;98% (SDS-PAGE).\u003cbr\u003e\u003cbr\u003e Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza). \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e CHO cells \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eInterleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).\u003cp\u003eThis recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"25UG","offer_id":40402738151620,"sku":"IMSIL21RNLRFCLY25UG","price":508.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_0cbb777f-1e62-435e-94f9-54a469bfa7fd.jpg?v=1740021308","url":"https:\/\/www.innov-research.com\/products\/mouse-il-21r-non-lytic-recombinant-protein-fc-tag-lyophilized-25ug","provider":"Innovative Research","version":"1.0","type":"link"}