{"product_id":"mouse-dr6-cytoplasmic-domain-recombinant-protein-c-terminal-his-tag-50ug","title":"Mouse DR6 Cytoplasmic Domain Recombinant Protein C-terminal His Tag","description":"\u003cp\u003eMouse DR6 Cytoplasmic Domain Recombinant Protein C-terminal His Tag from Innovative Research has been recombinantly produced in E. coli. This is a Liquid protein buffered in 1X PBS containing 10% glycerol with a purity of ~95%.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Mouse \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e TNFRSF21\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ~95% \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e E. coli \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store in working aliquots at -70°C. Avoid freeze\/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3). The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.\u003cp\u003eThis recombinant protein can be used for WB and ELISA. For research use only. . At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"50UG","offer_id":40786423840964,"sku":"IMSDR6CYPLARCTHIS50UG","price":365.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_a22654cd-bb28-432a-9e24-a1e33907dc96.jpg?v=1740023975","url":"https:\/\/www.innov-research.com\/products\/mouse-dr6-cytoplasmic-domain-recombinant-protein-c-terminal-his-tag-50ug","provider":"Innovative Research","version":"1.0","type":"link"}