*Innovative Grade Prekallikrein Knockout Mouse

*Innovative Grade Prekallikrein Knockout Mouse

  • $850.00
  • Featured Pricing

Tech Questions? Ask an Expert!

We're here to help. Send us your questions, and our team will get back to you with your question answered, your problem solved!

Select this product for Molecular Innovations name, Prekallikrein Knockout Mouse and product number, MS-PK.

At Innovative Research, we have worked to establish a broad range of working mouse research models to support many different therapeutic and disease areas of research. Our mouse models are fully licensed and maintained as live colonies on-site in our Novi, MI facility under the care of full-time animal husbandry staff as well as on-site scientific and veterinary care.

This allows us to quickly and easily provide you with the exact mouse models for research that you need, including knockout mice, transgenic mice, and more. Because these research models are maintained as live colonies, they are immediately available - allowing you to skip the time and expense of add-on line items like cryogenic recovery and breeding fees.

Our live mouse research models are available as single, unique mice as well as breeding pairs with an annual breeding license (contact us for details on breeding pairs). We are able to accommodate most requests, including age and gender requirements.

Our Prekallikrein Knockout Mouse Models were created via targeted gene disruption using CRISPR-Cas9 technology licensed from the Broad Institute of MIT and Harvard targeting KLKB1. Mutations were then confirmed using various methods, including PCR genotyping and Sanger sequencing, and the complete absence of Plasma Kallikrein B (Prekallikrein) protein in the plasma of homozygous mice was confirmed by Western Blot. This research model is useful for a wide range of scientific studies, including research into coagulation and fibrinolysis and related disease and disorders.

Prekallikrein is the inactive zymogen precursor of Kallikrein. Our Prekallikrein Knockout Mouse Models are available as homozygous mice that demonstrate a greatly extended clotting time, as this deficiency impacts the early phase of the intrinsic pathway of the coagulation cascade. Kinin formation and fibrinolysis may also be impacted, as well as the contact activation system.

Mouse Model Details:

  • Strain: C57BL6/SJL
  • Chromosome: 8
  • Gene: KLKB1
  • Genomic Target: Exon 1
  • Mutation: 5 Base Pair Deletion
  • Phenotype: Extended clotting time

In addition to the live mouse models, we also offer a line of ready-to-use, genetically deficient plasma, organs, and tissue lysates that are ideal for use in applications like ELISA, Western Blot, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

You've got questions, we've got answers!

We're here to help. Send us your questions, and our team will get back to you with your question answered, your problem solved!