Innovative Grade PAI-1 Knockin Mouse

Innovative Grade PAI-1 Knockin Mouse

IGMSKIPAI1NPNP
  • $2,790.00


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Select this product for Molecular Innovations name, PAI-1 Knockin Mice and product number, MS-PAI-R124A-NP.

At Innovative Research, we have worked to establish a broad range of working mouse research models to support many different therapeutic and disease areas of research. Our mouse models are fully licensed and maintained as live colonies on-site in our Novi, MI facility under the care of full-time animal husbandry staff as well as on-site scientific and veterinary care.

This allows us to quickly and easily provide you with the exact mouse models for research that you need, including knockin mice, transgenic mice, and more. Because these research models are maintained as live colonies, they are immediately available, allowing you to skip the time and expense of add-on line items like cryogenic recovery and breeding fees.

Our live mouse research models are available as single, unique mice as well as breeding pairs with an annual breeding license (contact us for details on breeding pairs). We are able to accommodate most requests, including age and gender requirements.

Our Plasminogen Activator Inhibitor-1 (PAI-1) knockin mouse model was created by targeted substitution of critical amino acids using programed nuclease. A single amino acid point mutation results in PAI-1 with reduced binding to the serum protein vitronectin. This research model is useful for a wide range of scientific studies, including research related to cardiovascular disease, fibrinolysis, aging, and diabetes, among others.

Mouse Model Details:

  • Strain: C57BL6/SJL
  • Chromosome: 5
  • Gene: SERPINE1
  • Genomic Target: Exon 2
  • Mutation: Arg124->Ala

In addition to the live mouse models, we also offer a line of ready-to-use, genetically deficient plasma, organs, and tissue lysates that are ideal for use in applications like ELISA, Western Blot, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

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