*Innovative Grade Factor IX Knockout Mouse

*Innovative Grade Factor IX Knockout Mouse

  • $850.00
  • Featured Pricing

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Select this product for Molecular Innovations name, Factor IX Knockout Mouse and product number, MS-FIX.

At Innovative Research, we have worked to establish a broad range of working mouse research models to support many different therapeutic and disease areas of research. Our mouse models are fully licensed and maintained as live colonies on-site in our Novi, MI facility under the care of full-time animal husbandry staff as well as on-site scientific and veterinary care.

This allows us to quickly and easily provide you with the exact mouse models for research that you need, including knockout mice, transgenic mice, and more. Because these research models are maintained as live colonies, they are immediately available, allowing you to skip the time and expense of add-on line items like cryogenic recovery and breeding fees.

Our live mouse research models are available as single, unique mice as well as breeding pairs with an annual breeding license (contact us for details on breeding pairs). We are able to accommodate most requests, including age and gender requirements.

Our Factor IX Knockout Mouse Model is a research model for human Hemophilia B, created via targeted disruption of the F9 gene using CRISPR-Cas9 technology licensed from the Broad Institute of MIT and Harvard. Mutations were then confirmed using various methods, including PCR genotyping, Sanger sequencing, and RT-PCR. Factor IX deficiency is the genetic cause of Hemophilia B, and this model can be useful for a wide range of research, including studies of gene therapies and pharmaceutical development.

Our Factor IX Mutant Mouse Models are available as male hemizygous mice, as Factor IX deficiency is an X-linked disorder. These mice have a hemophilia B phenotype with prolonged clotting time (confirmed via aPTT) as well as tail clipping-induced mortality in the absence of cauterization.

Mouse Model Details:

  • Strain: C57BL6/SJL
  • Chromosome: X
  • Gene: F9
  • Genomic Target: Exon 1
  • Mutation: 2 Base Pair Deletion
  • Phenotype: Prolonged clotting time (aPTT), tail clipping-induced mortality (in the absence of cauterization)

In addition to the live mouse models, we also offer a line of ready-to-use, genetically deficient plasma, organs, and tissue lysates that are ideal for use in applications like ELISA, Western Blot, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

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