{"product_id":"human-scd4-recombinant-protein-lyophilized-10ug","title":"Human sCD4 Recombinant Protein Lyophilized","description":"\u003cp\u003eHuman sCD4 Recombinant Protein Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in with a purity of ? 95% by SDS-PAGE gel and HPLC analyses..\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e CD4\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ? 95% by SDS-PAGE gel and HPLC analyses. \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e CHO cells \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze \/ thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eCluster determinant 4 (CD4), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction and T cell differentiation, development and activation. CD4 is constitutively expressed on the surface of various immune cells, including monocytes, macrophages, eosinophils, dendritic cells, and most prominently T lymphocytes, where it functions as an essential co-receptor and co-ligand for T cell receptor (TCR) and major histocompatibility complex class II (MHC-II) molecules. Ligation by MHC-II molecules on the surface of antigen-presenting cells can serve to influence adaptive immunity by facilitating helper T cell activation and macrophage differentiation, while ligation by proinflammatory cytokine IL-16 can contribute to innate immunity by chemoattracting CD4-expressing peripheral immune cells along an IL-16 gradient for their recruitment and activation at sites of inflammation. The protean functionality of CD4 extends past immunity as CD4 also notably serves as the major receptor for HIV-1 and human herpes virus 7 (HHV-7) infections. During HIV pathogenesis, CD4 acts instrumentally as a high-affinity entry receptor for the internalization of HIV-1 following binding of the viral envelope glycoprotein gp120 to CD4’s extracellular domain. CHO cell-derived Recombinant Human sCD4 is amonomeric glycoprotein of 371 amino acid residues, which correspond to the extracellular CD4 domain, and a calculated molecular weight of 41.3 kDa. As a result of glycosylation, Recombinant Human sCD4 migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-PAGE Gel analysis, under reducing conditions.\n\n\u003cp\u003e. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"10UG","offer_id":40752212115652,"sku":"IHUSCD4RLY10UG","price":336.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/products\/Enzymes-Proteins_5a2e96dc-e224-472c-9fa9-ffdd7694fd52.png?v=1633705581","url":"https:\/\/www.innov-research.com\/products\/human-scd4-recombinant-protein-lyophilized-10ug","provider":"Innovative Research","version":"1.0","type":"link"}