{"product_id":"human-il-1r1-recombinant-protein-c-fc-tag-lyophilized-50ug","title":"Human IL-1R1 Recombinant Protein C-Fc Tag Lyophilized","description":"Human IL-1R1 Recombinant Protein C-Fc Tag Lyophilized from Innovative Research has been recombinantly produced in Human cells. This is a Lyophilized protein buffered in Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100UG\/ml. Dissolve the lyophilized protein in ddH2O. with a purity of Greater than 95% as determined by reducing SDS-PAGE.Endotoxin level less than 0.1 ng\/ug (1 IEU\/ug) as determined by LAL test..More Details: Species: Human Target: IL1R1 Purity: Greater than 95% as determined by reducing SDS-PAGE.Endotoxin level less than 0.1 ng\/ug (1 IEU\/ug) as determined by LAL test. Source: Human cells Storage Conditions: Lyophilized protein should be stored at -20░C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7░C for 2-7 days.Aliquots of reconstituted samples are stable at -20░C for 3 months. \u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003eInterleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor\/coreceptor subunits. It also binds ligands with comparable affinity and binding of anTagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1 alpha or IL1? but not IL1ra, was identified. Recombinant IL1 soluble receptor Type I is a potent anTagonist of IL1 action. This recombinant protein can be used for biological assays. For research use only. . At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.","brand":"Innovative Research","offers":[{"title":"50UG","offer_id":40681331720388,"sku":"IHUIL1R1RCFCLY50UG","price":722.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_25248163-5c1c-4fca-baaa-c381b78ae186.jpg?v=1740023152","url":"https:\/\/www.innov-research.com\/products\/human-il-1r1-recombinant-protein-c-fc-tag-lyophilized-50ug","provider":"Innovative Research","version":"1.0","type":"link"}