{"product_id":"human-ide-recombinant-protein-c-6his-tag","title":"Human IDE Recombinant Protein C-6His Tag","description":"\u003cp\u003eHuman IDE Recombinant Protein C-6His Tag from Innovative Research has been recombinantly produced in Human Cells. The protein formulation is supplied as a 0.2 ?m filtered solution of 20mM TrisHCl,150mM NaCl,0.05%Brij35,10%Glycerol,pH7.5. with a purity of \u0026gt; 95 % as determined by reducing SDS-PAGE..\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e IDE\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e \u0026gt; 95 % as determined by reducing SDS-PAGE..\u0026lt; 1.0 EU per ug as determined by the LAL method.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e Human Cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInsulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid ?-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF ? and ?-endorphin.\u003c\/p\u003e\u003cp\u003eAt Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"10ug","offer_id":41176622268612,"sku":"IHUIDERC6HIS10UG","price":394.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_23b479e7-d337-44b0-baac-bb5953309f47.jpg?v=1740024327","url":"https:\/\/www.innov-research.com\/products\/human-ide-recombinant-protein-c-6his-tag","provider":"Innovative Research","version":"1.0","type":"link"}