{"product_id":"human-cd4-fragment-recombinant-protein-his-tag-c-terminal-n-terminal-strepii-tag-50ug","title":"Human CD4 Fragment Recombinant Protein His Tag C-terminal, N-terminal strepII-Tag","description":"\u003cp\u003eHuman CD4 Fragment Recombinant Protein His Tag C-terminal, N-terminal strepII-Tag from Innovative Research has been recombinantly produced in E. coli. This is a Liquid protein buffered in 100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol with a purity of ~90%.\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e CD4\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ~90% \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e E. coli \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Store in working aliquots at -70°C. Avoid freeze\/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eCD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response (1). On T-lymphocytes, it defines the helper\/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120 (2). This soluble CD4 fragment (sCD4) will work in HIV neutralization assays at levels comparable to previously published results. The minor upper band seen in the Coomassie blue-stained gel is likely to be due to the presence of uncleaved signal sequence. \u003cp\u003eThis recombinant protein can be used for WB and ELISA. For research use only. . At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"50UG","offer_id":40786422464708,"sku":"IHUCD4FRGRHISCTNTS250UG","price":365.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/products\/Enzymes-Proteins_03b45bf8-72a9-4bbe-80b1-ca1d70f0e9a3.png?v=1634317897","url":"https:\/\/www.innov-research.com\/products\/human-cd4-fragment-recombinant-protein-his-tag-c-terminal-n-terminal-strepii-tag-50ug","provider":"Innovative Research","version":"1.0","type":"link"}