{"product_id":"human-cd152-ctla-4-recombinant-protein-fc-tag-lyophilized-500ug","title":"Human CD152 [CTLA-4] Recombinant Protein Fc Tag Lyophilized","description":"Human CD152 [CTLA-4] Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 1mg\/ml in sterile water. Add 1X PBS to the desired protein concentration. with a purity of \u0026gt;98% (SDS-PAGE). Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza)..More Details: Species: Human Target: CTLA4 Purity: \u0026gt;98% (SDS-PAGE). Endotoxin level is less than 0.06EU\/ and#956;g protein (LAL test; Lonza). Source: CHO cells Storage Conditions: Stable for at least 1 year after receipt when stored at -20░C. Working aliquots are stable for up to 3 months when stored at -20░C. \u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003eCD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.","brand":"Innovative Research","offers":[{"title":"500UG","offer_id":40374205579460,"sku":"IHUCD152CTLA4RFCLY500UG","price":678.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/products\/Enzymes-Proteins_aeb07d37-30cd-4c84-83c6-138b5670d470.png?v=1628886774","url":"https:\/\/www.innov-research.com\/products\/human-cd152-ctla-4-recombinant-protein-fc-tag-lyophilized-500ug","provider":"Innovative Research","version":"1.0","type":"link"}