{"product_id":"bacteria-derived-tau-441-2n4r-recombinant-protein-his-tag-lyophilized","title":"Bacteria-Derived Tau-441 \/ 2N4R Recombinant Protein His Tag Lyophilized","description":"\u003cp\u003eBacteria-Derived Tau-441 \/ 2N4R Recombinant Protein His Tag Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5 with a purity of \u0026gt;90% as determined by reduced SDS-PAGE. .\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Bacteria-Derived \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e MAPT\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e \u0026gt;90% as determined by reduced SDS-PAGE. \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e E. coli \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles. \u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/p\u003e\u003cbr\u003eTau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as \"2N4R,\" \"Isoform Tau-F,\" \"Tau-4\" or \"Tau 441\", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.\u003cp\u003eThis protein carries a polyhistidine Tag at the N-terminal. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"100ug","offer_id":40245469610180,"sku":"IBCTTAU4412N4RRHISLY100UG","price":902.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/products\/Enzymes-Proteins_1d304bcc-688e-4a11-a56e-00f6e5926fd0.png?v=1627670686","url":"https:\/\/www.innov-research.com\/products\/bacteria-derived-tau-441-2n4r-recombinant-protein-his-tag-lyophilized","provider":"Innovative Research","version":"1.0","type":"link"}