{"product_id":"bacteria-derived-htra2-active-recombinant-protein-c-his-tag-lyophilized","title":"Bacteria-Derived HtrA2 Active Recombinant Protein C-His Tag Lyophilized","description":"\u003cp\u003eBacteria-Derived HtrA2 Recombinant Protein C-His Tag Lyophilized from Innovative Research has been recombinantly produced in E.coli. The protein formulation is lyophilized from sterile 50mM Tris, 0.3M NaCl, 1mM DTT, 20% Glycerol, pH 7.8 with a purity of \u0026gt; 87 % as determined by reducing SDS-PAGE..\u003c\/p\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eMore Details:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eSpecies:\u003c\/b\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTarget:\u003c\/b\u003e HtrA2\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e \u0026gt; 87 % as determined by reducing SDS-PAGE..Please contact us for more information.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSource:\u003c\/b\u003e E.coli\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage Conditions:\u003c\/b\u003e Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20? for 3 months.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eSerine  protease HTRA2, also known as high temperature requirement protein A2, Omi  stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and  HTRA2, is a single-pass membrane protein which belongs to the peptidase  S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine  protease that shows proteolytic activity against a non-specific substrate  beta-casein. It promotes or induces cell death either by direct binding to and  inhibition of BIRC proteins (also called inhibitor of apoptosis proteins,  IAPs), leading to an increase in caspase activity, or by a BIRC  inhibition-independent, caspase-independent and serine protease  activity-dependent mechanism. HTRA2 cleaves THAP5 and promotes its degradation  during apoptosis. Isoform 2 of HTRA2 seems to be proteolytically inactive.  Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) which is a  complex neurodegenerative disorder characterized by bradykinesia, resting  tremor, muscular rigidity and postural instability, as well as by a clinically  significant response to treatment with levodopa.\u003c\/p\u003e\u003cp\u003eAt Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.\u003c\/p\u003e\u003cp\u003eFor research use only.\u003c\/p\u003e","brand":"Innovative Research","offers":[{"title":"100ug","offer_id":41176602247364,"sku":"IBCTHTRA2ARCHISLY100UG","price":921.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0050\/2297\/4065\/files\/66211b8b-ccf5-459c-bd40-6ec9ff2c4d10_f75bd4a5-63fb-4a7e-ac05-beb38ebac9b5.jpg?v=1740024107","url":"https:\/\/www.innov-research.com\/products\/bacteria-derived-htra2-active-recombinant-protein-c-his-tag-lyophilized","provider":"Innovative Research","version":"1.0","type":"link"}