Recombinant Human Factor XIIa
Recombinant Human Factor XIIa is activated from insect cell culture derived Factor XII by an autoactivation process with Dextran Sulfate followed by repurification. Complete activation is observed on SDS-PAGE. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. The protein purity is determined by SDS-PAGE and activity is determined via complementation in an APTT clotting assay using Factor XII immuno-deficient human plasma. Specific activity of this recombinant product is typically lower than that of plasma derived material. Custom mutants of Factor XII are also available, please contact us for more details.