Recombinant human Factor XII
Recombinant Human Factor XII is a single chain glycoprotein produced in insect cell culture. Factor XII is converted, principally from the action of kallikrein, into an active serine protease (Factor alpha-Xlla) that functions in the in vivo initiation of blood coagulation, fibrinolysis, and kinin formation. The protein purity is determined by SDS-PAGE and activity is determined via complementation in an APTT clotting assay using Factor XII immuno-deficient human plasma. Specific activity of this recombinant product is typically lower than that of plasma derived material. Custom mutants of Factor XII are also available, please contact us for more details.