Recombinant Equine TNF alpha
Recombinant Equine TNF alpha (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor-alpha or TNF-) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages (M1), although it can be produced by other cell types as well like CD4 lymphocytes and NK cells. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL1 & IL6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF production has been implicated in a variety of human diseases, including Alzheimer's disease,cancer,major depression,and inflammatory bowel disease (IBD).