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Human Plasma

Pooled Normal Human Plasma

Catalog No.: IPLA-N

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Product Description

Pooled Normal Human Plasma


Innovative Research's Pooled Normal Human Plasma is processed from single donors via apheresis plasma units. The material undergoes viral testing, and the final product is aliquoted to customer specifications. Each unit is tested and found negative for HBsAg, HCV, HIV-1, HIV-2, HIV-1Ag or HIV 1-NAT, ALT, and syphilis by FDA-approved methods.

This material is sold for in-vitro use only in manufacturing and research. This material is not suitable for human use. It is the responsibility of the user to undertake sufficient verification and testing to determine the suitability of each products application. The statements herein are offered for informational purposes only and are intended to be used solely for your consideration, investigation, and verification.

DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS

SANDEEP REDDY KUNATI
Cleveland State University, May 2018

... Six pooled blank mouse plasmas lots containing sodium heparin anticoagulant with specific lot numbers (IR11-BCNaH-0928, 11140-01, 11140-02, 11140-03, 11140-04, and 11140-05) were purchased from Innovative Research (Novi, MI, USA) ... Blank pooled human plasma and six lots of blank human plasma (EDTA-treated) were purchased from Innovative Research (Novi, MI, USA).

(3-22-18)

Fluorometric detection of EGFR exon 19 deletion mutation in lung cancer cells using graphene oxide

Dong-Min Kim, Dong Ho Kim, Woong Jung, Kye Young Lee and Dong-Eun Kim
Analyst, 2018. First Published 15 Mar 2018.

... USA) supplemented with 10% fetal bovine serum (Hyclone) and 100 U mL-1 penicillin (WelGene, Daegu, Korea). Pooled normal human plasma was obtained from Innovative Research (Novi, MI, USA). Genomic DNA extraction ...

(1-31-18)

Determination of free thyroid hormones in animal serum/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry

Rumi Tanoue, Imari Kume, Yasuo Yamamoto, Kohki Takaguchi, Kei Nomiyama, Shinsuke Tanabe, Tatsuya Kunisue
Journal of Chromatography A, 31 January 2018

... 1) and bovine (no. 2) in this article) were purchased from SigmaAldrich (St. Louis, MO, USA). Pooled each human and feline plasma was purchased from Innovative Research (Novi, MI, USA) and Aviva Systems Biology (San Diego, CA, USA), respectively ...

(7-14-17)

HTML A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

X Bao, J Wu, N Sanai, J Li - Journal of Pharmaceutical Analysis, 2017
... Drug-free (blank) human plasma from six different healthy donors and pooled plasma (with Na-EDTA anticoagulant) were purchased from Innovative Research Inc. (Novi, MI, USA). 2.2. Chromatographic and mass-spectrometric conditions. 2.2.1. Instrumentation. ...

(August, 2017)

Determination of LongR 3-IGF-I, R 3-IGF-I, Des1-3 IGF-I and their metabolites in human plasma samples by means of LC-MS

A Thomas, K Walpurgis, P Delahaut, E Fichant - Hormone & IGF Research, 2017
... 2.4. Human blood samples. A commercially available plasma pool was used for all validation experiments (Pooled normal human plasma, Coagulant: EDTA, Innovative Research, Novi, MI). Ten plasma samples from healthy ...

(April 17, 2017)

Uncovering Structural Diversity of Unsaturated Fatty Acyls in Cholesteryl Esters via Photochemical Reaction and Tandem Mass Spectrometry


Jia Ren, Elissia T. Franklin, Yu Xia
... Pooled normal human plasma with anticoagulant lithium heparin was obtained from (Innovative Research, Novi, MI). ....

(July 2017)

Performance of the SAMBA I and II HIV-1 Semi-Q Tests for viral load monitoring at the point-of-care


N Goel, AV Ritchie, S Mtapuri-Zinyowera, C Zeh - Journal of Virological , 2017
... with pooled normal plasma that was both negative for HIV-1 RNA, antibodies to HIV-1 or to HIV-2, antibodies to hepatitis C virus (HCV), HCV RNA, and hepatitis B surface antigen (HBsAg) as well as nonreactive in a screening test for syphilis (Innovative Research, Novi, MI). ....

(2-28-2017)

Stability studies of potent opioid analgesic, morphine6Osulfate in various buffers and biological matrices by HPLCDAD analysis

JSK Yadlapalli, ZAF Albayati, NR Penthala - Biomedical , 2017
... cardiovascular effects, constipation, and hyperalgesia. It has been shown by many researchers that structural modification of the 3-O- ... standards (USP). Rat and Human plasma were purchased from innovative research, Novi, MI. ...

(2-14-17)

Targeted proteomics and absolute protein quantification for the construction of a stoichiometric host-pathogen surface density model


K Sjholm, O Kilsgrd, J Teleman, L Happonen - Molecular & Cellular , 2017
... Plasma adsorption Human blood plasma (pooled healthy human plasma Na-citrate, Innovative Research, Novi, MI, USA) was mixed with bacteria, in a ratio 3:1, and the samples were incubated for 30 minutes at 37C, allowing plasma proteins to adsorb to the bacterial surface. ...

(8-30-2016)

Performance evaluation of the point-of-care SAMBA I and II HIV-1 Qual whole blood tests


AV Ritchie, N Goel, H Sembongi, J Lehga, LE Farleigh - Journal of Virological,2016
... in a pool of normal commercially sourced plasma negative for HIV-1 RNA, antibodies to HIV-1 or to HIV-2, antibodies to hepatitis C virus (HCV), HCV RNA, and hepatitis B surface antigen as well as nonreactive in a screening test for syphilis (Innovative Research, Novi, MI, USA...

(6-7-16)

An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775


Wu, N Sanai, X Bao, P LoRusso, J Li - Journal of Chromatography B, 2016
... ... Drug-free (blank) human plasma from six different healthy donors and pooled plasma (with Na EDTA anticoagulant) were purchased from Innovative Research Inc. (Novi, MI, USA).

(5-17-16)

18 F FMeNER-D2: A systematic in vitro analysis of radio-metabolism


C Rami-Mark, N Eberherr, N Berrotern-Infante - Nuclear Medicine and , 2016
... Pooled human and rat plasma (Li Heparin) was obtained from Innovative Research (MI, USA). Therefore, 10 L of the radiotracer were incubated in 500 L pooled human plasma (Innovative Research, Peary Court Novi, Li Heparin, X1693B) at 37 C using a thermomixer ...

(5-17-16)

Reducible Micelleplexes are Stable Systems for Anti-miRNA Delivery in Cerebrospinal Fluid


Y Zhang, JS Buhrman, Y Liu, JE Rayahin - Molecular Pharmaceutics, 2016
... Louis, MO). Anti-coagulated (citrate) human plasma was purchased from Innovative Research (Novi, MI). The University of Illinois at Chicago Institutional Review Board (IRB) reviewed the protocol and approved the study as exempt human research...

(5-12-16)

Resveratrol counters systemic lupus erythematosus-associated atherogenicity by normalizing cholesterol efflux


I Voloshyna, I Teboul, MJ Littlefield, NM Siegart - Experimental Biology and , 2016
... ... THP-1 macrophages were incubated in 12-well plates for 18 h in RPMI medium under the following eight conditions: (1) 10% fetal calf serum; (2) 10% pooled normal human plasma (Innovative Research, Novi, MI)

(3-15-16)

Reduced In Vivo Toxicity of Doxorubicin by Encapsulation in Cholesterol-Containing Self-Assembled Nanoparticles


L Gonzalez-Fajardo, LH Mahajan, D Ndaya - Pharmacological Research, 2016
... Human plasma and plasma from BALB/c mice were purchased from Innovative Research (Novi, MI, USA).

(2-10-16)

PDF Alastair B. Ross*, Cecilia Svelander, Otto I. Savolainen, Mads Vendelbo Lind


JP Kirwan, I Breton, JP Godin, AS Sandberg - 2016
... A pooled ethylenediaminetetraacetic acid (EDTA) plasma sample from US donors (Innovative-Research, Novi, MI, USA), and EDTA- plasma from a Swedish donor with coeliac disease (no intake of wheat, rye or barley) were used for method validation. ...

(1-5-2016)

Endomorphin Analog Analgesics with Reduced Abuse Liability, Respiratory Depression, Motor Impairment, Tolerance, and Glial Activation


JE Zadina, MR Nilges, J Morgenweck, X Zhang - Neuropharmacology, 2015
... To test analog degradation by human and rat plasma enzymes in vitro, pooled normal human plasma was obtained from Innovative Research (Novi, MI, cat.IPLA-N) and rat aortic blood was drawn in a 10ml syringe rinsed with heparin, incubated at room temperature 1 hr and ...

(1-5-16)

Multiplex Preamplification of Serum DNA to Facilitate Reliable Detection of Extremely Rare Cancer Mutations in Circulating DNA by Digital PCR


JB Jackson, DS Choi, JD Luketich, A Pennathur - The Journal of Molecular , 2016
... Extraction of ccfDNA from pooled normal human plasma (wild-type control; Innovative Research, Novi, MI) and patient serum (1 to 3 mL per patient) was performed...

(1-2-16)

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound


BP Mead, P Mastorakos, JS Suk, AL Klibanov, J Hanes - Journal of Controlled , 2015
... Effective shielding of the NP positive surface charge was confirmed by the near-neutral -potential ( 1.5 0.3 mV; Table 1). We further measured the stability of DNA-BPN in pooled human plasma (PHP; Innovative Research, Novi, MI); DNA-BPN retained their colloidal stability ...

(12-22-15)

Development and validation of a highly sensitive LCMS/MS method for the determination of acacetin in human plasma and its application to a protein binding study


SB Kim, T Lee, HS Lee, CK Song, HJ Cho, DD Kim - Archives of Pharmacal Research
... Sang-Bum KimAffiliated withNew Drug Development Center, DaeguGyeongbuk Medical Innovation Foundation; , Taehun LeeAffiliated withCollege of ... Pooled normal human plasma (from donors aged 1865 years) was purchased from Innovative Research (Novi, MI, USA). ...

(10-27-15)

Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer


ER Gaddes, D Lee, G Gydush, Y Wang, C Dong - Experimental cell research, 2015
... Pooled human plasma was purchased from Innovative Research (Novi, MI) and all DNA sequences were obtained from Integrated DNA Technologies (Coralville, IA). The protein standard was purchased ...

(9-18-15)

Nanoscale plasma coating inhibits formation of Staphylococcus aureus biofilm


Y Xu, JE Jones, H Yu, Q Yu, GD Christensen, M Chen - Antimicrobial Agents and , 2015
... The sterilized coupons were then coated by overnight incubation in 135 20% (v/v) dilution of human plasma (Innovative Research, Novi, MI) in phosphate-buffered 136 saline (PBS). Coupons coated with human plasma were incubated in 1 ml Todd-Hewitt broth 137 ...

(8-27-15)

P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms


MG McDonald, NT Au, AE Rettie - Drug Metabolism and Disposition, 2015
... Pooled human plasma from healthy individuals, containing sodium citrate as an anticoagulant, was obtained from Innovative Research (Novi, MI). Cytochrome P450 Supersomes TM and Bactosomes TM , expressed from cDNA using baculovirus infected insect cells, were, ...

(6-17-15)

A rapid LCMRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine Noxide and creatinine in human plasma and urine


X Zhao, S Zeisel, S Zhang - ELECTROPHORESIS, 2015
... USA). 2.2 Plasma and urine collection Pooled human plasma was purchased from Innovative Research (Novi, MI, USA), which was collected from single donors of age between 18 and 65. The plasma was acidified by adding...

(5-22-15)

Biomonitoring of Perfluorinated Compounds in a Drop of Blood


P Mao, D Wang - Environmental Science & Technology, 2015
... methanol in polypropylene vials. All glassware was rinsed with methanol before use. For plasma samples spiked with PFCs, frozen pooled human plasma was obtained from Innovative Research Inc. (Novi, MI). A 5 L aliquot ...

(4-13-15)

Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression


ME Klegerman, AK Naji, KJ Haworth, Y Zou, E Golunski - of Liposome Research, 2015
... For release studies, one 5-mg BEV-ELIP or FITC-BEV-ELIP aliquot was reconstituted with 0.5 ml of nanopure water and added to 49.5 ml of PBS, human plasma (Innovative Research, Novi, MI) or porcine plasma (Innovative Research).

(2-24-15)

Species-Dependent Chelation of 241Am by DTPA Di-Ethyl Ester


JE Huckle, MP Sadgrove, RJ Mumper, M Jay - Health Physics, 2015
...separation. The 241 Am(NO 3 ) 3 stock solution was obtained from Eckert & Ziegler Isotope Products (Valencia, CA, USA). Rat, beagle and human plasma were obtained from Innovative Research Inc. (Novi, MI, USA). Pierce...

(2-21-15)

Plasma IL33 in atopic patients correlates with proinflammatory cytokines and changes cholesterol transport protein expression: a surprising neutral overall impact


I Voloshyna, T Mucci, J Sher, LS Fonacier, MJ Littlefield - Clinical & Experimental , 2015
... in RPMI medium containing each of the following: 10% FCS; 10% pooled normal human plasma (Innovative Research, Novi, MI); 10% plasma from each HC; 10% plasma from each AP. No FCS was added to cells incubated in human plasma.

(2-14-15)

Inactivation of myeloperoxidase by benzoic acid hydrazide


J Huang, F Smith, JR Panizzi, DC Goodwin, P Panizzi - Archives of Biochemistry and , 2015
Human plasma and fetal bovine serum were purchased from Innovative Research Inc. (Novi, MI). For protein staining, Gelcode Blue was purchased from...

(2-10-15)

Determination of triapine, a ribonucleotide reductase inhibitor, in human plasma by liquid chromatography tandem mass spectrometry


Y Feng, CA Kunos, Y Xu - Biomedical Chromatography, 2015
Six lots of human blank plasma (EDTA-treated), six lots of human blank sera, and pooled human blank plasma were purchased from Innovative Research (Novi, MI, USA). Preparation of stock and standard solutions...

(1-25-15)

N-Acetyl-S-(N, N-diethylcarbamoyl) Cysteine in Rat Nucleus Accumbens, medial Prefrontal Cortex, and in RAT and Human Plasma after Disulfiram Administration


RD Winefield, AAM Heemskerk, S Kaul, TD Williams - Journal of Pharmaceutical , 2015
Nanopure water was prepared using a Water Pro Plus purification system (Labconco,Kansas City, MO, USA). Blank pooled human plasma was purchased from Innovative Research (Novi, MI, USA). 2.2. Synthesis of DETC-NAC and DIPC-NAC.

(11-18-14)

Determination of the Rifamycin Antibiotics Rifabutin, Rifampin, Rifapentine and their Major Metabolites in Human Plasma via Simultaneous Extraction Coupled with


LC Winchester, AT Podany, JS Baldwin, BL Robbins - Journal of Pharmaceutical , 2014
Fisher Scientific (Fairlawn, NJ). Type I water (H 2 O) was produced in the laboratory using a Millipore MilliQ Integral 3 system. Human (K 2 EDTA) plasma was purchased from Innovative Research (Novi, MI).

(10-11-14)

Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease


J Markowitz, TR Brooks, MC Duggan, BK Paul, X Pan - Cancer Immunology 2014
progressive disease, 17 patients were evaluated. Plasma from normal donors (n =9, ages 3562) was pur- chased from Innovative Research, Inc. (Novi, MI). Page 3. Cancer Immunol Immunother 1 3 MDSC immunophenotyping

(9-12-14)

Systemic Investigation on Quinoxaline Derivatization of Sialic Acid and Its Quantitative Application for Biosamples


L Wang, D Wang, X Zhou, L Wu, XL Sun - RSC Advances, 2014.
Fetal bovine serum was purchased from Innovative Research (Novi, MI,USA). Human plasma was purchased from Innovative Research (Novi, MI, USA). UV pectroscopy monitoring of the stability of penyldiamines and their SA quinoxaline derivatives...

(9-2-14)

Improvements to the Fluoride Reactivation Method by Simple Organic Extraction for Retrospective Detection of Exposure to the Organophosphorus Nerve Agents in


JY Lee, YH Lee - International Journal of Analytical Mass Spectrometry , 2014
2.3. Sample Preparation 2.3.1. Incubation of Plasma Samples with GB Human plasma which was purchased from Innovative Research (Innovative Research, Peary Court, Novi, MI, USA) was incubated with GB to inhibit cholinesterase.

(8-28-14)

Bioinspired affinity DNA polymers on nanoparticles for drug sequestration and detoxification


N Chen, Y Huang, Y Wang - Biomaterials, 2014
The pooled normal human plasma (supplemented with sodium heparin) was ordered from Innovative research (Novi, MI).

(8-22-14)

A Chiral HPLC-MS/MS Method for Simultaneous Quantification of Warfarin Enantiomers and its Major Hydroxylation Metabolites of CYP2C9 and CYP3A4 in Human


W Ju, K Peng, S Yang, H Sun, M Sampson, MZ Wang - Austin J Anal Pharm Chem, 2014
Optima-grade water: acetonitrile: methanol: and acetic acid was obtained from Fisher Scientific (Pittsburgh: PA: USA). Blank human plasma (collected in K2-EDTA tubes) was purchased from Innovative Research (Novi: MI: USA).

(8-13-14)

Characterization of physical properties of tissue factor containing microvesicles and a comparison of ultracentrifuge-based recovery procedures


C Ettelaie, MEW Collier, A Maraveyas, R Ettelaie - Journal of Extracellular Vesicles, 2014
TF-tGFP possessed similar TF activity to unconjugated TF, in agreement with our previous data (8). Microvesicles were also recovered from the plasma of diseased (colorectal cancer and cardiovascular patients) or normal subjects (Innovative Research, Novi, MI, USA) (11) and

(6-23-14)

Antibodies to PhnD inhibit staphylococcal biofilms


H Lam, A Kesselly, S Stegalkina, H Kleanthous - Infection and Immunity, 2014
log phase in TSB, then harvested by low speed centrifugation, resuspended in an equal 189 volume of filtered (0.45 m) 100% human plasma (Innovative Research, Novi, MI), and 190 grown for an additional 3 h

(6-11-14)

Measurement of plasma protein and lipoprotein binding of pyrethroids


PK Sethi, S Muralidhara, JV Bruckner, CA White - Journal of Pharmacological and, 2014
Frozen, heparinized, pooled adult human and rat plasma were obtained from Innovative Research (Novi, MI, USA). The plasma was stored at -80 C until use.

(4-11-14)

Novel oral anti-influenza drug candidate AV5080


AV Ivachtchenko, YA Ivanenkov, OD Mitkin - Journal of Antimicrobial, 2014
Pooled human plasma in sodium citrate, Sprague Dawley rat plasma and canine plasma (mixed breed) in Na 2 EDTA were obtained from Innovative Research (Novi, MI, USA). Universal buffer was obtained from pION-Inc.

(3-31-14)

in vitro and in vivo Activity of HPi1, a Selective Antimicrobial against Helicobacter pylori


E Gavrish, B Shrestha, C Chen, I Lister, EJ North - Antimicrobial Agents and , 2014
158 Waters and colleagues (22). HPi1 (10 M) was incubated in human plasma (Innovative Research 159 INC; Novi, MI) for 4 h and after acetonitrile-mediated protein precipitation and filtration, quantification 160 of unbound...

(1-8-2014)

Ceramides and cardiac function in children with chronic kidney disease


M Mitsnefes, PE Scherer, LA Friedman, R Gordillo... - Pediatric Nephrology, 2014
This was accomplished by dividing the metabolite level in the sample by the averagemetabolite level in the pooled normal plasma control. Pooled normal human plasma was purchased from Innovative Research (Novi, MI, USA). Statistical analysis...

(10-16-13)

A stable isotope-labeled internal standard is essential for correcting for the interindividual variability in the recovery of lapatinib from cancer patient plasma in...


J Wu, R Wiegand, P LoRusso, J Li - Journal of Chromatography B, 2013
...throughout in all aqueous solutions. Blank pooled human plasma and six different donors of plasma were obtained from Innovative Research Inc. (Novi, MI). 2.2. Stock solutions, calibration standards, and quality control samples.

(9-2-13)

Plasma from rheumatoid arthritis patients promotes pro-atherogenic cholesterol transport gene expression in THP-1 human macrophages


I Voloshyna, S Modayil, MJ Littlefield, E Belilos... - Experimental Biology and ..., 2013
...THP-1 macrophages were incubated in 12-well plates for 18 h in RPMI medium containing each of the following: 10% fetal calf serum; 10% pooled normal human plasma (Innovative Research, Novi, MI); 10% plasma from each HC; 10% plasma from each RA patient...

(5-3-13)

Rapid Quantitative Evaluation of Amphotericin B in Human Plasma, by Validated HPLC Method


P Balabathula, DR Janagam, NK Mittal... - J Bioequiv ..., 2013 - omicsonline.org
...Biomedicals (Santa Ana, CA, USA) and HPLC grade methanol, acetonitrile, dimethyl sulfoxide (DMSO), acetic acid and water were obtained from Fisher (Pittsburg, PA, USA). Drug-free human plasma was purchased from Innovative Research (Novi, MI, USA)...

(4-16-13)

Group classification based on high-dimensional data: application to differential scanning calorimetry plasma thermogram analysis of cervical cancer and control ...


SN Rai, J Pan, A Cambon, JB Chaires, NC Garbett - 2013
...Thus, each thermogram comprised 451 data points and, with duplicate measurements, 902 data points for each subject. The Normal group comprised 100 commercial plasma samples purchased from Innovative Research (Novi, MI, USA) ...

(10-15-2012)

Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm


Y Ma, Y Xu, BD Yestrepsky, RJ Sorenson, M Chen - 2012
...Twenty ul of culture supernatant was added to 100 ul phosphate buffered saline (PBS), 10 ul human plasma (Innovative Research, Novi, MI), and10 ul S2403 (1 mg/ml) (Diapharma group Inc., West Chester, OH) and incubated at 37uC for 2 hours...

(10-15-12)

Oversulfated Chondroitin Sulfate Inhibits the Complement Classical Pathway by Potentiating C1 Inhibitor


ZH Zhou, M Rajabi, T Chen, E Karnaukhova... - PLOS ONE, 2012
...Normal pooled human plasma was purchased from Innovative Research (Novi, Michigan)...

(9-1-12)

Comparative protein binding of Taxotere and SID530, a new docetaxel formulation with hydroxypropyl-beta-cyclodextrin, in human plasma in vitro


TK Kim, HH Yoo, EJ Kim, JH Sa, BY Lee, JH Park - Die Pharmazie-An International ..., 2012
... Aventis (Paris, France). Human plasma was purchased from Innovative Research (Novi, MI, USA). The rapid equilibrium dialysis (RED) plate was purchased from Thermo Scientific (Rockford, IL, USA). Docetaxel (analytical...

(8-2012)

High Performance Liquid Chromatography Mass Spectrometry Assay for Polymyxin B1 and B2 in Human Plasma


TA Thomas, EC Broun, KM Abildskov... - Therapeutic Drug ..., 2012 - journals.lww.com
...were from Waters (Milford, MA). Acetonitrile and water used were LC/MS grade purchased from Fisher Scientific. Blank human ethylenediaminetetraacetic acid (EDTA) plasma was obtained from Innovative Research (Novi, MI).

(6-28-12)

A new derivatization method coupled with LC-MS/MS to enable baseline separation and quantification of dimethylarginines in human plasma from patients to receive ...


Y Hui, M Wong, J Kim, J Love, DM Ansley... - ..., 2012 - Wiley Online Library
...phase extraction disk were purchased from Varian Inc. (Palo Alto, CA, USA). Commercial pooled human plasma was from Innovative Research (Novi, MI, USA). 2.3 Preparation of calibration standards...

(4-13-12)

Complement C1 Esterase Inhibitor Levels Linked to Infections and Contaminated Heparin-Associated Adverse Events


ZH Zhou, T Chen, K Arora, K Hyams, S Kozlowski - PloS one, 2012 - dx.plos.org
Normal human plasma and purified human prekallikrein was purchased from Innovative Research (Novi, Michigan).

(2-20-12)

Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the gamma-secretase inhibitor RO4929097


J Wu, PM LoRusso, LH Matherly... - Clinical Cancer Research, 2012 - AACRbr>...Louis, MO). Human, rat, mouse, and beagle plasma, and human blood were obtained from Innovative Research Inc. (Novi, MI). pGL3-Basic vector, pRL-SV40 expression construct, and the dual- luciferase reporter assay system were obtained from Promega (Madison, WI).

(12-14-11)

Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer


JD Warren, W Xiong, AM Bunker, CP Vaughn... - BMC ..., 2011 - biomedcentral.com
...Analytical performance of the assay was determined using CpGenome wholly methylated human genomic DNA (Chemicon/Millipore, Billerica, Massachusetts) added to pooled normal human plasma (Innovative Research, Novi, Michigan)...

(10-11-11)

An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry ...


S Peters, E Kaal, I Horsting... - Journal of Chromatography A, 2011 - Elsevier
...from Sigma-Aldrich (Zwijndrecht, The Netherlands). Commercial human plasma was purchased from Innovative Research (Novi, Michigan, US). Methanol, sodium acetate, ethylenediaminetetraacetic acid...

(10-5-11)

Development and validation of a comprehensive two-dimensional gas chromatographymass spectrometry method for the analysis of phytosterol oxidation products ...


M Menndez-Carreo, H Steenbergen... - Analytical and ..., 2012 - Springer
...Torrance, CA, USA). Pooled human plasma prepared using Na-EDTA as the anti-coagulant was purchased from Innovative Research (Novi, MI, USA). Samples were stored at -80 C until analysis. POP reference compounds...

(7-20-11)

Stable-Isotope Labeled Hydrophobic Hydrazide Reagents for the Relative Quantification of N-linked Glycans by Electrospray Ionization Mass Spectrometry


SH Walker, J Budhathoki-Uprety, BM Novak... - Analytical ..., 2011 - ACS Publications
...(Andover, MA). Pooled human plasma was purchased from Innovative Research (Novi, MI). IntegraFrit and PicoFrit capillaries were purchased from New Objective (Woburn, MA). These columns were packed in-house with TSK-Gel Amide-80 stationary...

(5-3-11)

Hydrophobic derivatization of N-linked glycans for increased ion abundance in electrospray ionization mass spectrometry


SH Walker, LM Lilley, MF Enamorado... - Journal of The American ..., 2011 - Springer
...Pooled human plasma was purchased from Innovative Research (Novi, MI, USA). High performance liquid chromatography grade acetonitrile (ACN), water, and methanol (MeOH) were all purchased from Burdick and Jackson (Muskegon, MI, USA). IntegraFrit and PicoFrit...

(1-15-11)

Functional Polymorphisms of the Coagulation Factor II Gene (F2) and Susceptibility to Systemic Lupus Erythematosus


S Manzi, MI Kamboh - The Journal of ..., 2011 - jrheum.org
...The absorbance, which is proportional to prothrombin activity in the sample, was measured at 405 nm. Serial dilutions of pooled human plasma (Innovative Research, Novi, MI, USA) were used as the standard. Statistical methods...

(11-26-10)

3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties


J Zhu, Y Hu, MKC Ho, YH Wong - Xenobiotica, 2011 - ingentaconnect.com
...(St. Louis, MO). Human plasma was purchased from Innovative Research Inc. (Novi, MI). Pooled rat (male) and human (male) liver microsomes (RLM and HLM) were obtained...

(11-12-10)

A sensitive LCMS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8, 10-diynoic acid isobutylamide in human ...


AKL Goey, RW Sparidans, I Meijerman... - ... of Chromatography B, 2011 - Elsevier
..and formic acid were purchased from Merck (Darmstadt, Germany). Blank, drug-free human plasma, containing heparin (Li) as anti-coagulant, was obtained from Innovative Research Inc. (Novi, MI, USA). 2.2. Instrumentation...

(11-2-10)

LC-MS/MS method for the determination of carbamathione in human plasma


L van Haandel, JM Woods... - ... of Pharmaceutical and ..., 2011 - Elsevier
...City, MO, USA). Blank pooled human plasma was purchased from Innovative Research (Novi, MI, USA). 2.2. Synthesis of internal standard candidates. 2.2.1. General procedure for S(N-alkylcarbamoyl)glutathione derivatives...

(10-16-10)

Rapid and sensitive LCMS/MS method for determination of felbamate in mouse plasma and tissues and human plasma


RJ Hansen, BJ Samber... - Journal of Chromatography B, 2010 - Elsevier
...Louis, MO). Pooled blank sodium heparin collected mouse and human plasma was purchased from Innovative Research (Novi, MI). Mouse tissues were obtained from untreated mice obtained from lab animal resources (LAR) at Colorado State University.

(8-3-10)

A disposable system for rapid purification of autologous plasmin as an adjunct to vitrectomy performance and safety profile


M Hermel, W Dailey, M Trese, MK Hartzer - Graefe's Archive for Clinical ..., 2011 - Springer
...excluding the bias of possible variation of plasminogen levels in donor blood, 32 consecutive preparations were performed by the same experienced investigator using one lot of commercially available pooled human plasma (Innovative Research Inc., Novi, MI, USA)...

(7-21-10)

Determination of esmolol and metabolite enantiomers within human plasma using chiral column chromatography


L Fang, C Bykowski-Jurkiewicz, JG Sarver... - ... of Chromatography B, 2010 - Elsevier
...Louis, MO, USA). All other chemicals and reagents were purchased from common commercial sources and used without further purification. Human plasma was purchased from Innovative Research (Novi, MI, USA). 2.2. Instrumentation...

(5-27-10)

One-year plasma N-linked glycome intra-individual and inter-individual variability in the chicken model of spontaneous ovarian adenocarcinoma


RB Dixon, MS Bereman, JN Petitte... - International Journal of ..., 2011 - Elsevier
...St Louis, MO). Pooled human plasma was purchased from Innovative Research (Novi, MI). Graphitized solid-phase extraction cartridges were purchased from Alltech (Deerfield, IL). HPLC grade acetonitrile...

(5-26-10)

Plasma Proteomic Analysis May Identify New Markers for Radiation-Induced Lung Toxicity in Patients With NonSmall-Cell Lung Cancer


XW Cai, K Shedden, X Ao, M Davis, XL Fu... - International Journal of ..., 2010 - Elsevier
...aliquoted in small quantity and stored at -80 until the day of experiment. Pooled normal human plasma was purchased from Innovative Research Inc. (Novi, MI) as a reference control. Proteomic analysis...

(3-5-10)

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune ...


SM Noe, MA Green, H HogenEsch, SL Hem - Vaccine, 2010 - Elsevier
...In vitro elution of IDCAS was studied by mixing 3 mL of the non-adsorbed, AP-adsorbed, and AH-adsorbed vaccines with 9 mL of human plasma (pooled normal human plasma with citrate anticoagulant, Innovative Research, Novi, MI) at 37 C. At appropriate intervals from 30...

(1-20-10)

The effects of abundant plasma protein depletion on global glycan profiling using NanoLC FT-ICR mass spectrometry


MS Bereman... - Analytical and bioanalytical chemistry, 2010 - Springer
...HPLC-grade acetonitrile and water were obtained from Burdick & Jackson (Muskegon, MI). Pooled human plasma was purchased from Innovative Research (Novi, MI). Graphitized solid-phase extraction cartridges were from Alltech (Deerfield, IL).

(5-12-09)

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC- FTICR Mass Spectrometry


MS Bereman, DD Young, A Deiters... - ... of Proteome Research, 2009 - ACS Publications
...Pooled human plasma was purchased from Innovative Research (Novi, MI). Graphitized solid phase extraction cartridges were from Alltech (Deerfield, IL), and drop dialysis membranes were from Millipore (Burlington, MA)...

(4-3-09)

A rational design approach for amino acid supplementation in hepatocyte culture


H Yang, CM Roth... - Biotechnology and ..., 2009 - Wiley Online Library
...Dulbecco's Modified Eagle's Medium (DMEM) with 4.5 g/L glucose, fetal bovine serum (FBS), penicillin and strepto- mycin were purchased from Invitrogen Corporation (Carlsbad, CA). Heparinized human plasma was obtained from Innovative Research, Inc. (Novi, MI).

(2-19-09)

Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release


X Lu, MD Howard, DR Talbert, JJ Rinehart... - The AAPS journal, 2009 - Springer
...USA). Bis(p-nitrophenyl) phosphate (BNPP) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Mouse and human plasma containing Na heparin were purchased from Innovative Research (Novi, MI, USA). Plasma from...

(1-28-09)

Simultaneous Determination of Zalcitabine and Stavudine in Maternal Plasma, Amniotic Fluid, Placental, and Fetal Tissues Using Reversed Phase on Silica Liquid ...


M Xu, CA White, MG Bartlett - Journal of Liquid Chromatography & ..., 2009 - Taylor & Francis
...Fresh standard solutions were prepared for each day of analysis or validation. Calibration Curves. Blank plasma was purchased from Innovative Research (Novi, MI, USA). Blank amniotic fluid, placenta, and fetal tissues were collected from untreated animals...

(1-6-09)

Absolute quantification of C-reactive protein in human plasma derived from patients with epithelial ovarian cancer utilizing protein cleavage isotope dilution mass ...


DK Williams Jr... - Journal of proteome research, 2009 - ACS Publications
...A total of 110 human plasma samples were analyzed: 1 pooled sample purchased from Innovative Research, Inc. (Novi, MI), 1 pooled sample from the Red Cross, and 108 samples procured from the Mayo Clinic (Rochester, MN).

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