Human Plasma

Normal Single Donor Human Plasma

Catalog No.: IPLA-N-S

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Product Description

Normal Single Donor Human Plasma

Innovative Research's Normal Single Donor Human Plasma is collected from healthy individuals in an FDA-approved collection center. The whole blood is collected and processed into plasma via centrifugation and frozen immediately after processing. Each unit is tested and found negative for HBsAg, HCV, HIV-1, HIV-2, HIV-1Ag or HIV 1-NAT, ALT, and syphilis by FDA-approved methods.

Innovative Research has a wide network of collection centers, and can collect from nearly any donor type. Our single donor human plasma can be collected from a variety of genders, races, and ages. If specific donor information is required, please contact us.

This material is sold for in-vitro use only in manufacturing and research. This material is not suitable for human use. It is the responsibility of the user to undertake sufficient verification and testing to determine the suitability of each products application. The statements herein are offered for informational purposes only and are intended to be used solely for your consideration, investigation, and verification.

Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains

Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara
The Protein Journal, 26 September 2018

"... The actual receptor ligand(s) in apolipoprotein B100, one of the main proteins of LLP, remain(s) unknown. The objective of this study was to identify true receptor ligand(s) in apo B100, a molecule of 4563 residues... LDL Purification Highly purified preparations of low-density lipoproteins were obtained from single donor human plasma with sodium-EDTA added at time of collection (Innovative Research Corporation, Novi, MI). LDL was ..."

Development and validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Pavan Kumar Prathipati, Subhra Mandal, Christopher J. Destache
Biomedical Chromatography, September 2018

" ... A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantification of bictegravir in human plasma... Dipotassium ethylenediaminetetraacetic acid (K2EDTA) plasma was purchased from Innovative Research (Novi, MI)... Six different sources of K2EDTA human blank plasma were extracted and the peak areas at the retention time of analyte and internal standard were compared to the peak areas found in the lower limit of quantification (LLOQ, 1 ng/mL) to determine the selectivity of the assay..."

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

Rolf W. Sparidans, Wenlong Li, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen
Journal of Pharmaceutical and Biomedical Analysis, August 2018

" ... Several second and third generation ALK inhibitors have been introduced in recent years. A bioanalytical assay for simultaneous quantification of alectinib, brigatinib, and lorlatinib was developed and validated for human plasma. The method was also partially validated for diluted mouse plasma and tissue homogenates of brain, liver, kidney, and spleen ... plasma of individual humans was provided by Innovative Research (Novi, MI, USA). "

HIV Integrase Inhibitor Pharmacogenetics and Clinical Outcomes: An Exploratory Association Study

Derek E. Murrell
East Tennessee State University Digital Commons, August 2018

"...Briefly, a standard curve ranging from 10 ng/mL to 1,500 ng/mL was created for drugs of interest from respective stock solutions in a 50:50 ratio of acetonitrile and water, using blank human plasma (Innovative Research Inc Novi, MI). Verapamil, a drug which no subject was concurrently receiving, was used as the internal standard in acetonitrile and 1% formic acid in water (80:20)..."

Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML

Sandrine Niyongere, Nolwenn Lucas, Jun-Min Zhou, Samer Sansil, Anthony D. Pomicter, Maria E. Balasis, John Robinson, Jodi Kroeger, Qing Zhang, Yu Long Zhao, Markus Ball, Rami Komrokji, Alan List, Michael W. Deininger, Brooke L. Fridley, Valeria Santini, Eric Solary & Eric Padron
Nature: Lukemia, July 2018

"... Fifteen single donor healthy control plasma samples were purchased from Innovative Research (Innovative Research, Inc., Novi, MI) with an average age 66 (range 60-80) and a total of nine men and six women ..."

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study

Nobuki Kuwano, Takahiro A. Kato, Masato Mitsuhashi, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Takeshi Sakurai, Shigenobu Kanba
Journal of Affective Disorders, July 2018.

"...Since our sandwich ELISA method used a combination of 2 different target antibodies, such as anti-SNAP25 as a capture antibody, and anti-CD81, anti-SYP, anti-IL1beta, anti-IL6, anti-IL34, anti-TNFalpha, anti-TNFR1, or anti-OXR as a detection antibody, a purified or recombinant protein was not applicable as a quantification standard. Thus, we first screened various plasma samples obtained from commercial sources (Innovative Research..."

A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of valacyclovir and its metabolite acyclovir in mouse and human plasma

Jian Shi, Yongjun Hu, David E. Smith, Hao-Jie Zhu
Journal of Chromatography B: Volume 1092, 15 August 2018, Pages 447-452

... Blank human plasma was obtained from Innovative Research Inc. (Novi, MI) ... Five different lots of blank mouse and human plasma were used to assess the matrix effects. Two sets of samples were prepared. Set A: phosphate-buffered saline spiked with ACV (10, 2000 nM), VACV (10, 2000 nM) and ISs (200 nM); Set B: extracted plasma mixed with ACV (10, 2000 nM), VACV (10, 2000 nM) and ISs (200 nM). The percentage of matrix effect was calculated as (b / a) * 100, where a and b are the peak areas of ACV, VACV, and IS in sets A and B, respectively.

Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry

J.J.M. Rooda, P.J.A. Dormans, M.J. van Haren, J.H.M. Schellens, J.H. Beijnen, R.W. Sparidans
Journal of Chromatography B, May 2018

... For the evaluation of selectivity and matrix effect, human lithium-heparinized plasma of six individual donors was obtained from Innovative Research (Novi, MI, USA). 2.2. Synthesis of small molecular thiol-conjugates ...

Suppression of Wild-Type Amplification by Selectivity-Enhancing Agents in PCR Assays That Utilize SuperSelective Primers for the Detection of Rare Somatic Mutations

Diana Y.Vargas, Salvatore A.E. Marras, SanjayTyagi, Fred R.Kramer
The Journal of Molecular Diagnostics, April 2018

... Digested KRAS G12A mutant plasmid DNA was spiked into normal single-donor human plasma (IPLA-N-S; Innovative Research, Novi, MI). The plasma was first centrifuged at 5000 rpm for 5 minutes ...

An LC-MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial

Sandeep R.Kunati, Shuming Yang, Basem M.William, Yan Xu
Journal of Pharmaceutical and Biomedical Analyisis, July 2018

... Pittsburgh, PA, USA). Ammonium formate was from Sigma-Aldrich (St. Louis, MO, USA). Blank pooled human plasma and six lots of blank human plasma (EDTA-treated) were purchased from Innovative Research (Novi, MI, USA) ...


Cleveland State University, May 2018

... Six pooled blank mouse plasmas lots containing sodium heparin anticoagulant with specific lot numbers (IR11-BCNaH-0928, 11140-01, 11140-02, 11140-03, 11140-04, and 11140-05) were purchased from Innovative Research (Novi, MI, USA) ... Blank pooled human plasma and six lots of blank human plasma (EDTA-treated) were purchased from Innovative Research (Novi, MI, USA).

The determination of 5-methoxytryptophan in human plasma

George M. Anderson, Joshua T Eighmie - Journal of Chromatography B, Jan 5 2018

... (Novi, MI) and from the NIH-supported Yale Biorepository (New Haven, CT) SCX SPE and TBA ion pair HPLC system, the observed mean ( SD) plasma MeOTRP concentration in 10 individual healthy human volunteer specimens supplied by Innovative Research (7 males, 3 ...


Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin

Mervat Morsy Abbas Ahmed El-Gendy, Khaled G. Abdel-Wahhab, Fathia A. Mannaa, Ayman A. Farghaly, Ahmed M. A. El-Bondkly
....Twenty microliters of each culture supernatant was added to 100 L phosphate buffered saline (PBS), 10 L human plasma (Innovative Research, Novi, MI), and 10 L S2403 (1 mg mL 1 , Diapharma group Inc ...


Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype

X Guo, J L Koff, A B Moffitt, M Cinar, S Ramachandiran, Z Chen, J M Switchenko, M Mosunjac, S G Neill, K P Mann, M Bagirov, Y Du, Y Natkunam, H J Khoury, M R Rossi, W Harris, C R Flowers, I S Lossos, L H Boise, S S Dave, J Kowalski and L Bernal-Mizrachi
... The ABC-DLBCL lines OCI-LY10 and OCI-LY3 and the GCB-DLBCL lines OCI-LY1, OCI-LY2 and OCI-LY19 were maintained in Iscove's medium supplemented with 20% fresh human plasma (Innovative Research, Novi, MI, USA), 1% L-glutamine, 1 mM sodium pyruvate and 50 ...


Liquid chromatography tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma

JJM Rood, MTJ van Bussel, JHM Schellens - Journal of Chromatography , 2016
... West Sussex, UK). For the evaluation of selectivity and matrix effect, lithium-heparinized plasma and EDTA plasma of six individual human donors was obtained from Innovative Research (Novi, MI, USA). Pure water used for...


An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775

Wu, N Sanai, X Bao, P LoRusso, J Li - Journal of Chromatography B, 2016
... ... Drug-free (blank) human plasma from six different healthy donors and pooled plasma (with Na EDTA anticoagulant) were purchased from Innovative Research Inc. (Novi, MI, USA).


Drosophila Torsin protein regulates motor control and stress sensitivity and forms

P Nguyen, JB Seo, HM Ahn, YH Koh, YH Koh... appropriate antibodies. Two independent human plasma samples purchased from Innovative Research (Novi, MI, USA) were used for HTor1A and FMR1 co-immunoprecipitation experiments...


A high throughput method for LC-MS/MS determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake

AB Ross, C Svelander, OI Savolainen, MV Lind - Analytical Biochemistry, 2016
... A pooled ethylenediaminetetraacetic acid (EDTA) plasma sample from US donors (Innovative-Research, Novi, MI, USA), and EDTA-plasma from a Swedish donor with coeliac disease (no intake of wheat, rye or barley) were used for method validation. ...


Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in

JJM Rood, S van Hoppe, AH Schinkel, JHM Schellens - Journal of Pharmaceutical , 2015
... West Sussex, UK). For the evaluation of selectivity and matrix effect, human lithium-heparinized plasma of six individual donors were obtained from Innovative Research (Novi, MI, USA). 2.2. Chromatography and MS/MS method. ...


A Simple Protein Precipitation-based Simultaneous Quantification of Lovastatin and Its Active Metabolite Lovastatin Acid in Human Plasma by Ultra-Performance

J Wujian, P Kuan-wei, Y Sihyung, S Huijing, S Mario - J Chromatogr Sep Tech, 2015
...Optima-grade water, acetonitrile, methanol and acetic acid were obtained from Fisher Scientific (Pittsburgh, PA, USA). Blank human plasma (collected in K2-EDTA tubes) was purchased from Innovative Research (Novi, MI, USA). Instrument and chromatographic conditions...


Multivariate analysis of traumatic brain injury: development of an assessment score

JE Buonora, AM Yarnell, R Lazarus, M Mousseau - Name: Frontiers in , 2015
...123 This investigation involved two separate sets of control samples. The control samples for the study of 124 mild-moderate TBI consisted of thirty normal adult, age and gender matched, healthy volunteers 125 obtained commercially from Innovative Research (Novi, MI).


Determination of triapine, a ribonucleotide reductase inhibitor, in human plasma by liquid chromatography tandem mass spectrometry

Y Feng, CA Kunos, Y Xu - Biomedical Chromatography, 2015
Six lots of human blank plasma (EDTA-treated), six lots of human blank sera, and pooled human blank plasma were purchased from Innovative Research (Novi, MI, USA). Preparation of stock and standard solutions...


Insights into accelerated liposomal release of topotecan in plasma monitored by a non-invasive fluorescence spectroscopic method

KD Fugit, A Jyoti, M Upreti, BD Anderson - Journal of Controlled Release, 2014
Heparinized human plasma samples from seven healthy donors of different ethnicity were purchased from Innovative Research (Novi, MI), aliquoted and stored at -20 C. An additional complement-protected plasma sample was also obtained from the same source by special...


Endotoxin Detection in Human Plasma With ESP Sample Preparation Kit

VC EndoZyme, VC EndoLISA, LALT Reagents
E. coli N99 or Salmonella enterica Typhimurium LT2 strains. Rabbit plasma was obtained from project rabbits maintained by Capralogics (Harwick, MA). Human plasma was obtained from control patients by Innovative Research (Novi, MI)...


A stable isotope-labeled internal standard is essential for correcting for the interindividual variability in the recovery of lapatinib from cancer patient plasma in...

J Wu, R Wiegand, P LoRusso, J Li - Journal of Chromatography B, 2013
...throughout in all aqueous solutions. Blank pooled human plasma and six different donors of plasma were obtained from Innovative Research Inc. (Novi, MI). 2.2. Stock solutions, calibration standards, and quality control samples.


Development and Validation of an LC-MS/MS Method for Pharmacokinetic Study of Methoxyamine in Phase I Clinical Trial

S Yang, P Savvides, L Liu, SL Gerson, Y Xu - Journal of Chromatography B, 2012 - Elsevier
...Six individual human plasmas containing no detectable MX (ie, 1M2070-01,1M2070-02, 1M2070-03,1M2070-04, 1M2070-05, and 1M2070-06) were also obtained from Innovative Research (Novi, MI, USA) for the study of matrix effect...


Chemical methods for the detection of protein N-homocysteinylation via selective reactions with aldehydes

T Zang, S Dai, D Chen, BWK Lee, S Liu... - Analytical ..., 2009 - ACS Publications
...Louis, MO). Recombinant enzyme LuxS was prepared as previously described.(27) Single donor human plasma sodium citrate was from Innovative Research (Novi, MI)...

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Normal Single Donor Human Plasma

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