Non-enzymatic Human tPA
This human tPA has an active site serine to alanine mutation which renders it catalytically inactive. The mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). It is 90 percent single chain and retains exosite binding as well as other properties of wild type tPA. Recombinantly produced in insect cells.