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Mouse Interleukin Proteins

Mouse IL-2, Fc Fusion Protein

Catalog No.: IMIL2-FC

From $150 to $1795

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$150

Category: Proteins

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Product Description

Mouse IL-2, Fc Fusion Protein


Interleukin-2 (IL-2) is a O-glycosylated four alpha-helix bundle cytokine that is produced by T-cells in response to antigenic or mitogenic stimulation. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells and is required for T-cell proliferation and other activities crucial to regulation of the immune response. This Fc Fusion Protein is glycosylated and expressed as a chimera with the Fc region of mouse immunoglobulin. Fc fusion proteins are typically more stable and resistant to degradation and clearance than native cytokines. Fc fusion proteins appear as a dimer in SDS-PAGE under non-reducing conditions.

(7-13-16)

Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?

AH Zea, T Stewart, J Ascani, DJ Tate, B Finkel-Jimenez - PLOS ONE, 2016
... The concentration of 100ng/ml resulted in optimal activation of the IL-2R. Prior to harvest at day 10, cells were stimulated with 100 ng/ml of IL-2 (Innovative Research, Novi, MI). For the IL-2 receptor studies, we isolated RNA and protein after incubation with IL-2 for 21 hours...

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Mouse IL-2, Fc Fusion Protein

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