Human Binding Protein Proteins

Human Receptor Associated Protein (RAP)

Catalog No.: IRAP

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Product Description

Human Receptor Associated Protein (RAP)

Human Receptor Associated Protein is produced recombinantly in E. Coli. Suitable to block receptor function in uptake assays. Contains endotoxin which might trigger signaling events.

Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System

ALTEX preprint, published 08 July 2018
Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb and Kenneth E. Thummel

"The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in the rodent models, this time using a 3-dimensional proximal tubule microphysiological system incorporating primary human proximal tubule epithelial cells ... Human receptor-associated protein (RAP) was purchased from Innovative Research (Novi, MI) ... The effect of RAP on each intrinsic clearance was evaluated using ratio t-tests paired by kidney tissue donor (n=5 biological replicates, all from male donors)."


FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition

MC Brenner, W Krzyzanski, JZ Chou, PE Signore - Pharmaceutical Research, 2016
... Receptor associated protein (Cat. No. IRAP-514) was pre- pared by Innovative Research, Inc. (Novi, MI). The protein was expressed as a glutathione-S-transferase fusion protein in E.coli and purified by glutathione-agarose chromatography. ...


Molecular basis for globotriaosylceramide regulation and enzyme uptake in immortalized aortic endothelial cells from Fabry mice

XL Meng, TS Day, N McNeill, P Ashcraft, T Frischmuth - Journal of Inherited , 2016
...... 20- and 400-fold molar excess respectively. Neurotensin and RAP were obtained from Sigma and Innovative Research (Novi, MI) respectively. Uptake of agalsidase alfa and moss- aGal in FMEC2 was dose-dependent up to 40 g/ml tested (Supplementary Fig. ...


Vascular-directed TFPI overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development

S Pan, TA White, TA Witt, A Chiriac, CS Mueske... - ...research, 2009 - ncbi.nlm.nih.gov
...Soybean trypsin inhibitor, bovine serum albumin, heparin, heparinase I and III, collagenase type I, and elastase were purchased from Sigma-Aldrich Corp. (St. Louis, MO). RAP (receptor related protein) was purchased from Innovative Research (Novi, Michigan).


CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site

K Duus, NM Thielens, M Lacroix, P Tacnet... - FEBS ..., 2010 - Wiley Online Library
...Sigma. Human placenta-derived CD91 was from BioMac (Chamalires, France). RAP was from Innovative Research (Novi, Michigan, USA). Recombinant MBL was a generous gift of NatImmune (Kbenhavn , Denmark).


Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway

HT Gan, M Tham, S Hariharan... - Journal of ..., 2011 - Wiley Online Library
...numbers, cells were cultured for 7 days with human ApoE (Merck Biosciences, Darmstadt, Germany), recombinant human Apo E2, E3, E4 (Peprotech, Rocky Hill, NJ, USA), recombinant human receptor-associated protein (RAP; Innovative Research, Novi, MI, USA)...


Receptor-Associated Protein Blocks Internalization and Cytotoxicity of Myeloma Light Chain in Cultured Human Proximal Tubular Cells

S Sengul, S Erturk, AM Khan, V Batuman - PLOS ONE, 2013
The effect of human RAP (Innovative Research, Novi, MI) pre-treatment (1 M, 1 h) on the uptake of fluorescein isothiocyanate (FITC) labeled human myeloma LC (25 M) by human PTCs wastested by immunofluorescence microscopy and flow cytometry.


APOE genotypedependent modulation of astrocyte chemokine CCL3 production

E Cudaback, Y Yang, TJ Montine, CD Keene - Glia, 2014
from Calbiochem (La Jolla, CA, USA); Pam3CSK4 (Pam3) and CpG oligonucleotides were purchased from Invivogen (San Diego, CA, USA); low endotoxin recombinant human receptor associated protein (RAP) was purchased from Innovative Research (Novi, MI, USA)...


Different mechanisms of apolipoprotein E isoformdependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2...

X Li, KS Montine, CD Keene, TJ Montine - The FASEB Journal, 2015
Receptor-associated protein (RAP) was pur- chased from Innovative Research Inc.(Novi, MI, USA), and nu- clear factor k-light-chain-enhancer (NF-kB) inhibitor BAY 117085 from Enzo Life Science (Farmingdale, NY, USA).

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Human Receptor Associated Protein (RAP)

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