Human Renin Proteins

Human Prorenin 8x His

Catalog No.: IHPREN-HIS

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Category: Proteins

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Product Description

Human Prorenin 8x His

Recombinantly produced in HEK cell culture and purified by chelated metal affinity chromatography. Contains a 8X-Histidine tag at C terminus for purification. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus.


HTML A local renal reninangiotensin system activation via renal uptake of prorenin and angiotensinogen in diabetic rats

A Tojo, S Kinugasa, T Fujita, C Wilcox - Syndrome and Obesity: Targets and Therapy, 2016
... Administration of human prorenin and angiotensinogen. Rats were anesthetized for IV injections of 20 g recombinant human prorenin (Innovative Research Inc., Novi, MI, USA, dissolved in 0.2 mL saline)


Direct antiinflammatory effects of angiotensin(17) on microglia

M Liu, P Shi, C Sumners - Journal of Neurochemistry, 2015
... Human PRO was purchased from Innovative Research (Novi, MI). Immunocytochemistry Cultured microglial cells were washed with phosphate buffered saline (PBS; pH 7.2) and then fixed in 4% paraformaldehyde for 15 min at room temperature. ...

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Human Prorenin 8x His

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