Human Kallikrein Proteins

Human Kallikrein

Catalog No.: IHKa



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Product Description

Human Kallikrein

Activation of Prekallikrein with Factor a-XIIa produces the enzymatically active Kallikrein. Kallikrein is a serine protease which consists of a heavy chain (Mr 52kD) and light chains (Mr either 36 or 33 kD) linked by disulfide bridges. Kallikrein possesses enzymatic activity toward Factor XII, HK, Plasminogen, Factors XI, IX, and VII, prorenin and the complement system. After activation, the activating enzyme Factor XIIa is removed by affinity chromatography. Human Kallikrein purity is determined by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol.

Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1

J Dob, B Major, KA Kkesi, I Szab, M Megyeri... - PloS one, 2011 - dx.plos.org
...Human Kallikrein was purchased from Calbiochem (Darmstadt, Germany), or Innovative Research (Novi, MI): both of them were about the same good quality. Human plasma kallikrein (referred to as kallikrein) and human plasma prekallikrein...

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Human Kallikrein

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