Human Apolipoprotein E (ApoE)
Human APOE is 299 amino acids long and transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system, and then, into the blood. Apolipoprotein E is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. In the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of Apolipoprotein E, while neurons preferentially express the receptors for APOE.
Apo-E is a 34-37 kDa glycosylated protein. Concentration in normal plasma is 5 mg/dL and is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells.
High Purity Human Apolipoprotein E (ApoE) is purified from delipidated VLDL. Minor impurities are removed by affinity chromotography.
This product is for in vitro research use only, is not to be consumed by animals or humans, and should be handled with general precaution as if capable of spreading infectious disease.