Haptoglobin, Human Plasma
An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Haptoglobin binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes. Hp 1-1 is the most common, and the most effective in binding free hemoglobin. Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests. 95 percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion. Molecular Weights by phenotype - Hp 1-1: 86,000; Hp 2-1: 200,000; Hp 2-2: 400,000.