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ELISA Kit

Rat RANK ELISA Kit

Catalog No.: IRKTAH5531

$495

Category: Assay and ELISA Kits

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Product Description

Rat RANK ELISA Kit - 1 Kit (96 Wells)

Our Rat RANK ELISA Kit is a sandwich ELISA intended for the quantitative determination of rat RANK in cell culture supernates and serum.

Receptor Activator of Nuclear Factor ? B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain(residues 234-616), which contain three putative TRAF-binding domains(termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. The standard in this kit is recombinant human RANK with the sequence of Q29-G213 aa. It is a dipolymer which compose of two chains, and the molecular weight of each is 48kda.

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Rat RANK ELISA Kit

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