Rat CCL4/MIP-1 beta ELISA Kit - 1 Kit (96 Wells)Our Rat CCL4/MIP-1 beta ELISA Kit is a sandwich ELISA intended for the quantitative determination of rat CCL4 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).
Chemokine(C-C motif) ligand 4, also known as CCL4, is a protein which in mouse is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8 T cells. Performing-low memory CD8 T cells that normally synthesize MIP-1-beta. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. Based on functional analysis of MIP-1beta, one or more additional beta chemokine receptors that transduce MIP-1beta signals must also exist. MIP-1alpha and MIP-1beta have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many alpha as well as beta chemokines(11, 14).