Human TNFRSF18/GITR ELISA Kit - 1 Kit (96 Wells)Our Human TNFRSF18/GITR ELISA Kit is a sandwich ELISA intended for the quantitative determination of human TNFRSF18 in cell culture supernates, serum and plasma (heparin, EDTA).
Tumor necrosis factor receptor superfamily member 18(TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25()CD4() regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.