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ELISA Kit

Human PCSK9 ELISA Kit

Catalog No.: IRKTAH5208

$495

Category: Assay and ELISA Kits

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Product Description

Human PCSK9 ELISA Kit - 1 Kit (96 Wells)

Our Human PCSK9 ELISA Kit is a sandwich ELISA intended for the quantitative determination of human PCSK9 in cell culture supernates, serum and plasma (heparin, EDTA).

Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, the PCSK9 gene was mapped to chromosome 1p32. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A(EGF-A) domain of the low-density lipoprotein receptor(LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins(LDL), which could lead to hypercholesterolemia. PCSK9 may also have a role in the differentiation of cortical neurons.

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Human PCSK9 ELISA Kit

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