Human Chemerin/RARRES2 ELISA Kit - 1 Kit (96 Wells)Our Human Chemerin/RARRES2 ELISA Kit is a sandwich ELISA intended for the quantitative determination of human Chemerin in cell culture supernates, serum and plasma (heparin, EDTA).
Chemerin, also known as RARRES2 or TIG2, is a protein that in humans is encoded by the RARRES2 gene. It is mapped to 7q36.1. Chemerin is a potent chemoattractant specific for antigen-presenting cells that requires proteolytic activation and acts as a ligand for the G protein-coupled receptor CMKLR1(also known as ChemR23). It is a 14 kDa protein secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. Chemerin was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Whats more, the active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein.