Human CRLF2/TSLP R ELISA Kit - 1 Kit (96 Wells)Our Human CRLF2/TSLP R ELISA Kit is a sandwich ELISA intended for the quantitative determination of human CRLF2 in cell culture supernates, serum, and plasma (heparin, EDTA).
Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 gene. It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin(TSLP). Together with the interleukin 7 receptor(IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.