Human Angiopoietin-2 ELISA Kit

Catalog No.: IRKTAH5011


Category: Assay and ELISA Kits

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Product Description

Human Angiopoietin-2 ELISA Kit - 1 Kit (96 Wells)

Our Human Angiopoietin-2 ELISA Kit is a sandwich ELISA intended for the quantitative determination of human Angiopoietin-2 in cell culture supernates, serum, plasma (heparin, EDTA), saliva and human milk.

Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

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Human Angiopoietin-2 ELISA Kit

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