What Species Produce Polyclonal Antibodies?
Polyclonal antibodies are mixtures of related antibodies that are derived from blood serum, harvested from previously immunized animals. Serum-derived polyclonal antibodies can be produced in virtually any mammal. However, most polyclonal antibodies are produced in animals with large blood volumes like goats, rabbits, donkeys, and sheep.
An alternative source of polyclonal antibodies is egg yolk from birds like chickens and turkeys that have been immunized with antigens. Polyclonal antibodies isolated from egg yolk are of the IgY class. The IgY antibodies are functionally equivalent to IgG antibodies from mammals.