Do You Have An ELISA Kit For The Detection Of Serum Amyloid A (SAA) In The Rat?

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Written by admin on February 20, 2013. Posted in FAQs

We have been asked on many occasions if our SAA ELISA kit is cross-reactive with rat.

Published reports indicate that rat does indeed possess the gene for SAA, but that the gene contains a deletion. This gene appears to be transcribed and interestingly is under the control of a promoter, an inhibitory regulatory element, and a cytokine response element. Truncated mRNA for SAA can be detected, but the mature protein does not appear in serum or plasma samples.

References:

Yamada, T., N. Hirano, T. Kuoda, Y. Okuda, and Y. Ito (1997) Generation and characterization of rat monoclonal antibodies against human serum amyloid A. Scand. J. Immunol. 46(2):175-179.

Marhaug, G. and S.B. Dowton (1994) Serum amyloid A: An acute phase apolipoprotein and precursor of AA amyloid. Baillieres. Clin. Rheumatol. 8(3):553-573.

Li, L. and W.S. Liao (1999) An upstream repressor element that contributes to hepatocyte-specific expression of the rat serum amyloid A1 gene. Biochem. Biophys. Res. Commun. 264:395-403.

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