New Connection Between Circadian Rhythm and Cancer Progression

New Connection Between Circadian Rhythm and Cancer Progression

Posted by Leanne Kodsman on

Scientists have long known of a connection between the bodys circadian rhythm and gene movement and protein densities. A new study from researchers at University of California, Santa Cruz, focused on the connection between disrupting the circadian rhythm and the progression of cancer, has found a protein associated with cancer cells is able to suppress the circadian clock rather effectively, GEN News reports.


Scientists have long known of a connection between the bodys circadian rhythm and gene movement and protein densities. A new study from researchers at University of California, Santa Cruz, focused on the connection between disrupting the circadian rhythm and the progression of cancer, has found a protein associated with cancer cells is able to suppress the circadian clock rather effectively, GEN News reports.

Carrie Partch, Ph.D., senior author on the study said, The clock is not always disrupted in cancer cells, but studies have shown that disrupting circadian rhythms in mice causes tumors to grow faster, and one of the things the clock does is set restrictions on when cells can divide.

Dr. Partchs study focused on the protein PASD1. She hoped that by examining this protein her team would be able to uncover its involvement in rhythm disruption and find the beginnings for developing new therapies.

Circadian rhythms are regulated through a feedback loop which is controlled by genes and the proteins they encode. PASD1 was found to be similar in structure to one of the proteins in the feedback loop and can interfere with the complex that turns off the protein-producing genes.

By understanding what makes the clock tick and how it is regulated, we may be able to identify points where we can intervene pharmacologically to treat disorders in which the clock is disrupted, Dr. Partch said.


    Innovative Research was established in 1998 after the realization that dependable, high-quality, and affordable research materials were hard to come by. Starting with core products like human plasma and serum, Innovative Research has grown to be a trusted supplier of all lab reagents, including human biologicals and ELISA kits. Today, we manufacture and supply thousands of high-quality human and animal biologicals including plasma, serum, tissues, and proteins.


Related Posts

Holiday and New Year Shipping Schedule
As the holiday season approaches, we want to ensure that you receive your orders on tim...
Read the Article
People Behind The Science Podcast - Dr. Liu
People Behind the Science Innovative Research is proud to be a new sponsor of the podca...
Read the Article
Interview with Innovative Research CEO Donna Schelby
Earlier this month, Innovative Research CEO Donna Schelby sat down with Life Science Ma...
Read the Article

← Older Post Newer Post →

×