Product References — Pooled Human Complement Serum

Innovative Research's Human Complement was recently used in the following study: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica L Tradtrantip, X Yao, T Su, AJ Smith, AS Verkman - Acta Neuropathologica, 2017 ... Complement dependent cytotoxicity Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank's buffer, and cells were incubated at 37 °C for specified times. ...

May 31, 2017 Innovative Research's Pooled Complement Human Serum was recently used in the following study: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis opticaL Tradtrantip, X Yao, T Su, AJ Smith, AS Verkman - Acta Neuropathologica, 2017 ... Complement dependent cytotoxicity Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank's buffer, and cells were incubated at 37 C for specified times. ...

(May 2, 2017) Innovative Research's Pooled Complement Human Serum was recently used in the following study: Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytesZ Wang, W Guo, Y Liu, Y Gong, X Ding, K Shi, R Thome… - Brain, Behavior, and …, 2017 ... In a different set of experiments, 3 days after lentivirus injection, mice were injected in situ with 6 μl IgG NMO or IgG con with 4 μl human complement (hC) (Innovative Research, Novi, MI). The animals recovered normally without significant complication. ...

Innovative Research's Pooled Complement Human Serum was recently used in the following study: (11-3-15)Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explantsK Blauth, J Soltys, A Matschulat, CR Reiter, A Ritchie - Acta Neuropathologica, 2015... rAbs derived from MS patients and neuroinflammatory controls were applied to the media for 72 h at concentrations of 50 g/mL in the presence and absence of 10 % human complement (hComp) (pooled nor- mal human complement serum; Innovative Research, Novi, MI, USA ...

Innovative Research's Pooled Complement Human Serum was recently used in the following study: Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59H Zhang, AS Verkman - Journal of Autoimmunity, 2014Human complement (Innovative Research, Novi, MI) and NMO-IgG were then added in Hank's buffer, and cells were incubated at 28 C for 2 h. Cytotoxicity was measured by the Alamar Blue assay (Invitrogen). 2.5. NMO-IgG binding.