Product References — Human Plasma

Nucleic Acid Sample Preparation Using Magnetic Ionic Liquids as Cell Lysis and DNA Extraction Solvents

Posted by Adam Awdish on

Nucleic Acid Sample Preparation Using Magnetic Ionic Liquids as Cell Lysis and DNA Extraction Solvents

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Nucleic acid Sample Preparation Using Magnetic Ionic Liquids as Cell Lysis and DNA Extraction Solvents Miranda N. Emaus Iowa State University Graduate Theses and Dissertations 2021 When preparing DNA samples from cells with disrupted membranes, the first step on sample preparation is generally cell lysis. DNA is then extracted after cell lysis and then analysis of the nucleic acid is performed. However, current sample preparation methods are time consuming, multi-step processes. Magnetic ionic liquids (MILs) are salts in a molten form which are susceptible to...

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A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Posted by Adam Awdish on

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market Andrew M. Brandon, Lysbeth H. Antonides, Jennifer Riley, Ola Epemolu, Denise A. McKeown, Kevin D. Read, and Craig McKenzie Molecules March 5, 2021 A new, diverse group of synthetic drugs designed to activate human cannabinoid receptors CB1 and CB2 have emerged in the illicit drug market over recent years. These synthetic cannabinoid receptor agonists (SCRAs) have been...

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Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Posted by Adam Awdish on

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Innovative Grade US Origin Mouse CD1 Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment Jiashu Xie, Zhengqiang Wang Acta Pharmaceutica Sinica B March 5, 2021 To date, the only FDA-approved drug for treating COVID-19 is Remdesivir (RDV), which can only be administered intravenously. RDV is a ProTide drug derived from nucleoside GS-441524, and the potency of RDV is dependent on intracellular conversion into GS-441524 triphosphate. In vitro studies of RDV in human...

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α-Synuclein in Blood Exosomes Immunoprecipitated Using Neuronal and Oligodendroglial Markers Distinguishes Parkinson’s Disease from Multiple System Atrophy

Posted by Adam Awdish on

α-Synuclein in Blood Exosomes Immunoprecipitated Using Neuronal and Oligodendroglial Markers Distinguishes Parkinson’s Disease from Multiple System Atrophy

Pooled Human Plasma (Blood Derived) and Pooled Human Serum Off the Clot from Innovative Research were used in the following study:   α-Synuclein in Blood Exosomes Immunoprecipitated Using Neuronal and Oligodendroglial Markers Distinguishes Parkinson’s Disease from Multiple System Atrophy Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N. Maina, Irish del Rosario, Kimberly C. Paul, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Geidy E. Serrano, Charles H. Adler, Susan L. Perlman, Wayne W. Poon, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Karen H. Gylys, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz & Gal Bitan...

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A Universal Anti-Xa Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements: Method Validation, Diagnostic Accuracy and External Validation

Posted by Adam Awdish on

A Universal Anti-Xa Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements: Method Validation, Diagnostic Accuracy and External Validation

Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following study:   A Universal Anti-Xa Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements: Method Validation, Diagnostic Accuracy and External Validation Guido Willekens, Jan-Dirk Studt, Adriana Mendez, Lorenzo Alberio, Pierre Fontana, Walter A. Wuillemin, Adrian Schmidt, Lukas Graf, Bernhard Gerber, Cedric Bovet, Thomas C. Sauter, and Michael Nagler British Journal of Haematology March 19, 2021 When it comes to medical treatments and emergency care, any treatment involving anticoagulants naturally carries the risk of increased bleeding. In fact, uncontrolled bleeding is the leading cause of death in trauma patients. Knowing...

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