Product References — Human Biological Fluids

Human Alpha 2 Antiplasmin Purified Lyophilized from Innovative Research was used in the following study:   Plasminogen and Plasmin can Bind to Human T Cells and Generate Truncated CCL21 that Increases Dendritic Cell Chemotactic Responses Evert J. Loef, Hilary M. Sheppard, Nigel P. Birch, Rod Dunbar Journal of Biological Chemistry June 9, 2022 Plasmin, a broad-spectrum protease that is highly regulated, is formed from plasminogen. This normally occurs in the blood, as plasminogen is found in high concentrations in circulation where it’s converted to plasmin by plasminogen activators. There are also high levels of α2-antiplasmin in circulation, which is a...

Human Urokinase (uPA) Purified Two Chain High Molecular Weight, Human tPA 85% Single Chain Purified, and Human tPA 95% Two Chain Purified from Innovative Research were used in the following study:   Regulation of Serine Proteases in Blood Clotting and Beyond Fabienne Birkle PhD. Dissertation, University of Michigan 2022 Hemostasis is a complex, regulated bodily process that repairs vascular damage following injury. Three major parts make up the hemostatic system: blood clotting (coagulation), platelet activation, and vascular repair. Of these parts, coagulation plays the largest role. The coagulation cascade, established in the 1960s, describes a series of proteolytic cleavage reactions...

Human Neutrophil Elastase Purified Lyophilized from Innovative Research was used in the following study:   Neutrophil Elastase Aggravates Periodontitis by Disrupting Gingival Epithelial Barrier via Cleaving Cell Adhesion Molecules Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao Scientific Reports May 17, 2022 Neutrophil elastase (NE) is a proteinase found abundantly in the azurophilic granules of neutrophils. NE is an indicator of neutrophil activity and acts as a host defense mechanism against pathogens by degrading microbiological components during phagocytosis. Excessive NE activity, however, is undesirable because NE can destroy...

Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Detection of SARS-CoV-2 RNA through Tandem Isothermal Gene Amplification without Reverse Transcription Hyojin Lee, Hyobeen Lee, Sang-Hyun Hwang, Woong Jeong, Dong-Eun Kim Analytica Chimica Acta May 3, 2022 It has become clear over the last few years that, to stop the continuous spread of COVID-19 globally, rapid and accurate tests for the detection of SARS-CoV-2 must be developed. Nucleic acid testing is currently considered to be the best method for diagnosing SARS-CoV-2, however, the methods required to carry out the necessary testing, which are commonly...

Pooled Human Saliva from Innovative Research was used in the following study:   PD-LAMP Smartphone Detection of SARS-CoV-2 on Chip Ashlee J. Colbert, Dong Hoon Lee, Katherine N. Clayton, Steven T. Wereley, Jacqueline C. Linnes, Tamara L. Kinzer-Ursem Analytica Chimica Acta March 7, 2022 Part of why SARS-CoV-2 (COVID-19) has been able to reach pandemic levels is because it can have a long incubation period prior to the normal onset of symptoms, and further, it doesn’t always cause symptoms in infected individuals. On top of this, symptoms can range in severity between patients, and milder symptoms caused by COVID-19 can easily...