Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Posted by Adam Awdish on

Mouse Non-Swiss Albino Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:

 

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Shyam H. Kamble, Francisco León, Tamara I. King, Erin C. Berthold, Carolina Lopera-Londoño, Kanumuri Siva Rama Raju, Aidan J. Hampson, Abhisheak Sharma, Bonnie A. Avery, Lance R. McMahon, and Christopher R. McCurdy

ACS Pharmacology & Translational Science
July 31, 2020

Kratom is commonly used in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom, and 7-Hydroxymitragynine (7-HMG) is a mitragynine metabolite that is a more potent and efficacious opioid than its parent mitragynine.

In this recent study, researchers found that 7-HMG is stable in rodent and monkey plasma but is unstable in human plasma. This is because, in human plasma, 7-HMG is converted to an even more powerful opioid known as mitragynine pseudoindoxyl. Due to its potency, this novel metabolite may substantially contribute to the pharmacology of kratom in humans to a greater extent than in other tested species.

 

Related products available from Innovative Research also include:

Innovative Grade US Origin Mouse CD1 Plasma

Innovative Grade US Origin Monkey Cynomolgus Whole Blood

Single Donor Human Whole Blood

  • Tags: Animal Plasma, Human Plasma, Mouse Non Swiss Albino Plasma, Pooled Human Plasma Apheresis Derived

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