Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma
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Innovative Grade US Origin Guinea Pig Plasma from Innovative Research was recently used in the following study:
Journal of Chromatographic Science: 10 July 2018
Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma
Martin Kertys, Anna Urbanova, and Juraj MokryJournal of Chromatographic Science: 10 July 2018
" ... K3 EDTA guinea pig plasma (blank plasma) was purchased from Innovative Research (Novi, MI, USA) ... in this study we decided to develop a rapid, specific and sensitive method using LC"MS-MS coupled with an easy and fast sample preparation by protein precipitation for the TD, RF and RFN determination in guinea pig plasma. The method was fully validated in terms of selectivity, stability, linearity, precision and accuracy for guinea pig plasma... "
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